Fibrotic scarring: aging research evidence

HLifeOct 23

Mice lacking a lung protein developed worse lung scarring

In experiments with male mice, chemically induced lung scarring persisted at 56 days without the protein but had nearly resolved in mice with it.In experiments with male mice, chemically induced lung scarring persisted at 56 days without the protein but had nearly resolved in mice with it.

Mouse studyLung

Paper

bioRxivOct 23

Immune-cell enzyme is needed for scarless repair in animals

In animal experiments, disrupted remodeling of the material around cells impaired their response to injury and led to scarring.In animal experiments, disrupted remodeling of the material around cells impaired their response to injury and led to scarring.

Preprint: animal studyBlood and immune system

Paper

Cell ReportsOct 6

A protein helps zebrafish repair spinal cords without lasting scars

In zebrafish experiments, loss of Gata4 stiffened material around cells, delayed tissue rebuilding and impaired recovery of movement after spinal cord injury.In zebrafish experiments, loss of Gata4 stiffened material around cells, delayed tissue rebuilding and impaired recovery of movement after spinal cord injury.

Experiments in zebrafishMechanisms

Paper

EMBO Molecular MedicineOct 3

Prostaglandin E2 drives cellular senescence and scar fibrosis after cesarean section in mice

Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean defects.Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean defects.

Experiments in miceCellular senescence

Paper

GeroScienceSep 8