Experimental autoimmune encephalitis

1. Experimental autoimmune encephalitis increases cellular senescence in marmoset EAE.

   “elevated astrocytic and ependymal senescence signals marked perivascular and periventricular areas that later became demyelination hotspots.”

   Animalsin marmoset EAEperivascular and periventricular areas

   4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis-like lesions

   Science (New York, N.Y.)·Feb 27, 2025

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1. C9ORF72 protects against experimental autoimmune encephalitis in mice lacking one or both copies of C9orf72.

   “mice lacking one or both copies of C9orf72 are more susceptible to experimental autoimmune encephalitis”

   Animalsin mice lacking one or both copies of C9orf72

   C9orf72 in myeloid cells suppresses STING-induced inflammation

   Nature·Aug 19, 2020

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