Research Square
Common variants in the lysosomal pathway contribute to Parkinson's Disease risk
Preprint: cohort study of 7,668 peopleBiomarkers
Independent replication
Abstract
Objective Despite the progress in identifying an ever-increasing number of genetic loci implicated in Parkinson’s disease (PD), it has been increasingly recognised that pathway-based polygenic risk approaches could provide an alternative strategy to identify a subset of PD cases that might be more prone to pathway-specific susceptibility.
- Human genetics
- Autophagy
- Lysosome
- Parkinson's disease
- Lysosomal pathway-specific polygenic risk score
- Humans
The paper
University of Pavia; University of Tübingen
Research Square, 6 Aug 2026, CC BY, Preprint, not peer-reviewed
