Diabetes-related complications

There are 16 papers on diabetes-related complications in aging research: 6 observational studies in people, 5 reviews. The newest story, Nov 10, 2026: “Physical and mental deficits linked to diabetes progression”.

Disease

16 papers study it90 more mention it7 findings

8 new papers in 30 daysSee all 106 papers on diabetes-related complications

“T2D to complications (HR 1.36, 95% CI 1.19–1.57)”
Association of intrinsic capacity with the incidence and progression of type 2 diabetes, accounting for genetic risk: a prospective study using multi-state modelsMaturitas2026doi:10.1016/j.maturitas.2026.109187
  • Humans6
  • In silico5

Interventions

4

Exercise

downin reviews1

1 study
  1. Exercise decreases diabetes-related complications.

    “regular exercise is an effective non-pharmacological strategy to reduce diabetes-related complications”

    Review

    Exerkines in diabetic retinopathy: from mechanisms to therapeutic prospects

    Frontiers in endocrinology

More on Exercise

Tirzepatide

downin silico1

1 study
  1. Tirzepatide decreases diabetes-related complications in silico (simulated patients, UKPDS Outcomes Model 2 vs dulaglutide 0.75 mg).

    “tirzepatide 5 mg was associated with lower diabetes-related complication rates”

    In silicosimulated patients, UKPDS Outcomes Model 2 vs dulaglutide 0.75 mg5 mg50-year time horizon

    The Long-Term Cost-Effectiveness of Tirzepatide 5 mg versus Dulaglutide 0.75 mg for the Treatment of People with Type 2 Diabetes in Japan

    Diabetes therapy : research, treatment and education of diabetes and related disorders

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Metformin

downin humans1

1 study
  1. Metformin decreases diabetes-related complications in clinical use.

    “lowering hyperglycemia and diabetes-related complications in clinical use”

    Reviewin clinical use

    Function and therapeutic potential of metformin in multiple diseases

    Preprint

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SGLT2 inhibitors

downin silico1

1 study
  1. SGLT2 inhibitors decrease diabetes-related complications in silico.

    “Additional drug costs in pathway 1 were offset by diabetes-related complication decreases”

    In silicocompared with NPH insulin intensification in UK patients not at goal on metformin and sitagliptinlifetime

    Cost-effectiveness of intensification with sodium-glucose co-transporter-2 inhibitors in patients with type 2 diabetes on metformin and sitagliptin vs direct intensification with insulin in the United Kingdom

    Diabetes, obesity & metabolism

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Effects

1

Residual gastric contents

upin humans1

1 study
  1. Diabetes-related complications are linked with higher residual gastric contents in humans (aOR = 8.89 (3.15-25.12)).

    “Other significant risk factors for RGC included diabetes-related complications [aOR = 8.89 (3.15-25.12)].”

    Humansstomachn = 3,746

    Impact of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs) on Increased Residual Gastric Content in Patients With and Without Concurrent Colonoscopy: A Retrospective Case-Control Study

    Journal of clinical medicine

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Associations

2

Intrinsic capacity deficits

upin humans1HR 1.36

1 study
  1. Intrinsic capacity deficits are associated with diabetes-related complications in humans (HR 1.36, 95% CI 1.19–1.57).

    “T2D to complications (HR 1.36, 95% CI 1.19–1.57)”

    HumansTransition from type 2 diabetes to complications; ≥4 intrinsic capacity deficits versus no deficitsMedian follow-up of 13.63 years

    Physical and mental deficits linked to diabetes progression

    Maturitas

Low children educational attainment

upin humans1HR 1.14

1 study
  1. Low children educational attainment is associated with diabetes-related complications in humans among adults without other chronic diseases (HR 1.14; 95% CI, 1.05 to 1.24).

    “Having children with a lower educational level was associated with a higher hazard of complications (HRlow, 1.14; 95% CI, 1.05 to 1.24; HRmedium, 1.11; 95% CI, 1.05 to 1.17)”

    Humansamong adults without other chronic diseasesmean, 5.5 yearsn = 74,588

    The Association of Children and Their Educational Attainment With Diabetes-related Complications and Mortality Among Older Adults With Type 2 Diabetes: A Nationwide Cohort Study

    Canadian journal of diabetes

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Latest

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Maturitas

Physical and mental deficits linked to diabetes progression

Four or more physical and mental deficits were linked to higher diabetes risk than none over 13.63 years’ median follow-up (hazard ratio 2.37).Four or more physical and mental deficits were linked to higher diabetes risk than none over 13.63 years’ median follow-up (hazard ratio 2.37).

Cohort · 401,273 peopleIncident type 2 diabetes

See all 106 papers on diabetes-related complications