1 paper3 findings
Immune Risk Score
upin humans1HR 1.63
Immune Risk Score raises the risk of cognitively impaired no dementia in humans (HR = 1.63; 95% CI, 1.28-2.09).
“Higher IRS independently predicted incident CIND/dementia (HR = 1.63; 95% CI, 1.28-2.09)”
Humansn = 4,464
Immune cell profiles predict cognitive decline in older adults
Age and ageing1 Sep 2026
Naïve B cells
downin humans1HR 0.92
Naïve B cells lower the risk of cognitively impaired no dementia in humans (HR = 0.92, 95% CI: 0.87-0.98).
“naïve B cells independently predicted reduced cognitive impairment risk after full covariate adjustment (HR = 0.92, 95% CI: 0.86-0.98 and HR = 0.92, 95% CI: 0.87-0.98).”
Humansn = 4,464
Immune cell profiles predict cognitive decline in older adults
Age and ageing1 Sep 2026
CD56hi NK cells
downin humans1HR 0.92
CD56hi NK cells lower the risk of cognitively impaired no dementia in humans (HR = 0.92, 95% CI: 0.86-0.98).
“CD56hi NK cells and naïve B cells independently predicted reduced cognitive impairment risk after full covariate adjustment (HR = 0.92, 95% CI: 0.86-0.98”
Humansn = 4,464
Immune cell profiles predict cognitive decline in older adults
Age and ageing1 Sep 2026
A measure of prediction performance rose from 0.79 for symptoms alone to 0.90 when blood biomarkers were added.A measure of prediction performance rose from 0.79 for symptoms alone to 0.90 when blood biomarkers were added.
In an observational study of 735 people, other brain vessel injuries strengthened links between shorter sleep and brain lesions in some diagnostic groups.In an observational study of 735 people, other brain vessel injuries strengthened links between shorter sleep and brain lesions in some diagnostic groups.
Young and 18-month-old mice with an altered UCHL1 protein showed less white matter injury and better sensorimotor and cognitive performance in a dementia model.Young and 18-month-old mice with an altered UCHL1 protein showed less white matter injury and better sensorimotor and cognitive performance in a dementia model.
A 20-year longitudinal study finds earlier family bereavement is tied to higher cognitive impairment risk, with child loss remaining robust after health adjustments.A 20-year longitudinal study finds earlier family bereavement is tied to higher cognitive impairment risk, with child loss remaining robust after health adjustments.
In 4,464 cognitively normal older adults, a higher immune risk score predicted incident cognitive impairment or dementia with a hazard ratio of 1.63 over six years.In 4,464 cognitively normal older adults, a higher immune risk score predicted incident cognitive impairment or dementia with a hazard ratio of 1.63 over six years.
In 218 responders and controls aged 44 to 65, cortical thickness was associated with the WTC exposure severity index at R = -0.38.In 218 responders and controls aged 44 to 65, cortical thickness was associated with the WTC exposure severity index at R = -0.38.