Experiments in mice producing a progeria-linked protein in heart muscle cells found that restoring an RNA-marking protein partly reduced abnormal heart changes.Experiments in mice producing a progeria-linked protein in heart muscle cells found that restoring an RNA-marking protein partly reduced abnormal heart changes.
Experiments in Zmpste24−/− mice, 2 months, against AAV-cTnT-GFP-treated miceMechanisms
Limit: Reduced heart fibrosis does not directly demonstrate restored pumping function
In 14,462 independent recordings, predicted and actual ages had a correlation of 0.90, outperforming another model design and a model trained on a more uniform…In 14,462 independent recordings, predicted and actual ages had a correlation of 0.90, outperforming another model design and a model trained on a more uniform population.
Providing informal care was associated with 15% lower odds of cardiovascular disease, with a prevalence of 8.8% in carers compared to 12.8% in non-carers.Providing informal care was associated with 15% lower odds of cardiovascular disease, with a prevalence of 8.8% in carers compared to 12.8% in non-carers.
In an animal experiment, limiting daily eating hours altered gut bacteria and boosted acetic acid, easing high blood pressure and artery stiffness.In an animal experiment, limiting daily eating hours altered gut bacteria and boosted acetic acid, easing high blood pressure and artery stiffness.
In 17 human thoracic aorta samples, elastin stiffness, straightness, and lamellar length decreased significantly with age in males (p < 0.05) but not females.In 17 human thoracic aorta samples, elastin stiffness, straightness, and lamellar length decreased significantly with age in males (p < 0.05) but not females.