Cancer-associated cachexia

Disease

1 paper2 findings

  • Animals1

Effects

2

S100A9

upin mice1

1 study
  1. Cancer-associated cachexia increases S100A9 in mice.

    “identify S100A9 as a key factor selectively upregulated and secreted by brown adipocytes.”

    Animalsin a murine model of lung cancer-induced cachexiabrown adipose tissue

    Cancer cachexia induces senescent reprogramming of brown adipose tissue and pro-cachectic S100A9 secretion by adipocytes

    Cell death & disease2 May 2026

More on S100A9

Cellular senescence

upin mice1

1 study
  1. Cancer-associated cachexia induces cellular senescence in mice.

    “CAC induces a senescent conversion of BAT, marked by thermogenic failure, fibrosis, inflammation, and acquisition of a senescence-associated secretory phenotype (SASP).”

    Animalsin a murine model of lung cancer-induced cachexiabrown adipose tissue

    Cancer cachexia induces senescent reprogramming of brown adipose tissue and pro-cachectic S100A9 secretion by adipocytes

    Cell death & disease2 May 2026

More on Cellular senescence

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