Asthma in the elderly
3 papers study it3 more mention it3 findings
- Humans2
Effects
3Iron
downin human cells1
1 study
Iron
downin human cells1
Asthma in the elderly decreases iron in human cells.
“iron accumulates with aging, but surprisingly decreases with AIE.”
Cellsin hASMs from older patients with asthma (AIE)
Dysregulated iron metabolism in remodeling of aging asthmatic human airways
American journal of physiology. Cell physiologyJul 29, 2026
Cellular senescence
upin humans1
1 study
Cellular senescence
upin humans1
Asthma in the elderly increases cellular senescence in humans.
“Lung tissue or isolated ASM cells from elderly persons with asthma showed increased expression of multiple senescent markers including phospho-p53, p21, telomere-associated foci (TAF), as well as multiple SASP components.”
Humanselderly persons with asthmalung
Cellular senescence is increased in airway smooth muscle cells of elderly persons with asthma
American journal of physiology. Lung cellular and molecular physiologySep 27, 2022
Airway fibrosis
upin humans1
1 study
Airway fibrosis
upin humans1
Asthma in the elderly increases airway fibrosis in humans.
“Lung tissues from elderly persons with asthma showed greater airway fibrosis compared with age-matched elderly persons with nonasthma and young age controls.”
Humanselderly persons with asthma vs age-matched nonasthma and young controlslung
Cellular senescence is increased in airway smooth muscle cells of elderly persons with asthma
American journal of physiology. Lung cellular and molecular physiologySep 27, 2022
Trial sponsors
Rohr and Columbo Asthma, Allergy and Immunology Specialists, P.C.
1 trialPhase 330 people