Acute graft versus host disease
2 papers3 findings
- Animals2
Interventions
2Leucine restriction
downin mice1
1 study
Leucine restriction
downin mice1
Leucine restriction decreases acute graft versus host disease in mice.
“dietary restriction of L-Leu reduced aGVHD by controlling T cell expansion, inducing apoptosis, and affecting granzyme B secretion”
Animals
Restricting SLC7A5-mediated Leucine uptake in T cells prevents acute GVHD and maintains GVT response
EMBO molecular medicine21 May 2025
Human umbilical cord-derived mesenchymal stem cells
downin mice1
1 study
Human umbilical cord-derived mesenchymal stem cells
downin mice1
Human umbilical cord-derived mesenchymal stem cells decrease acute graft versus host disease in mice.
“transfusion of CRISPLD2-overexpressing HUC-MSCs ameliorated aGVHD while maintaining GVL activity.”
Animalsin an aGVHD murine model
Stem cell research & therapy1 May 2025
Upstream
1SLC7A5
downin mice1
1 study
SLC7A5
downin mice1
SLC7A5 decreases acute graft versus host disease in mice.
“SLC7A5 deletion affected T cell activation, expansion and survival, and reduced IFNγ and granzyme B expression, thus controlling aGVHD”
AnimalsT cell deletion
Restricting SLC7A5-mediated Leucine uptake in T cells prevents acute GVHD and maintains GVT response
EMBO molecular medicine21 May 2025
Trial sponsors
Company1 trialPhase 311 people
Novartis Pharmaceuticals Corporation
Company1 trialPhase 1/245 people
Company1 trialPhase 1/22 people
The First Affiliated Hospital of Soochow University
1 trialPhase 3190 people
1 trialPhase 3173 people
2 trialsPhase 2174 people
1 trialPhase 2157 people
H. Lee Moffitt Cancer Center and Research Institute
1 trialPhase 274 people