Leucine restriction

1. Leucine restriction improves graft-versus-tumor response in mice.

   “showed an increased proportion of central memory T cells, which contributed to the GVT response”

   Animals

   Restricting SLC7A5-mediated Leucine uptake in T cells prevents acute GVHD and maintains GVT response

   EMBO molecular medicine·21 May 2025

1. Leucine restriction decreases acute graft versus host disease in mice.

   “dietary restriction of L-Leu reduced aGVHD by controlling T cell expansion, inducing apoptosis, and affecting granzyme B secretion”

   Animals

   Restricting SLC7A5-mediated Leucine uptake in T cells prevents acute GVHD and maintains GVT response

   EMBO molecular medicine·21 May 2025

More on Acute graft versus host disease

1. Leucine restriction improves insulin sensitivity in mice.

   “MR and LR decreased body and fat mass, increased food intake, elevated lipid cycling in WAT and improved whole-body glucose metabolism and hepatic insulin sensitivity”

   Animals80% restriction8 weeksmales

   Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice

   Scientific reports·30 Aug 2017

1. Leucine restriction decreases body mass in mice.

   “MR and LR decreased body and fat mass, increased food intake, elevated lipid cycling in WAT and improved whole-body glucose metabolism”

   Animals80% restriction8 weeksmales

   Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice

   Scientific reports·30 Aug 2017