AgingResearch.NewsJoin free

CRISPLD2

Gene

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Key Research and Development Program of China and 1 more
  • Animals1

Effects

2

Mitochondrial damage

downin human cells1

1 study

  1. CRISPLD2 decreases mitochondrial damage in human cells.

    “CRISPLD2 overexpression overcomes the mitochondrial damage mediated by extracellular ATP and LPS in HUC-MSCs by inhibiting P2Y11 receptor signalling”

    Cellsin HUC-MSCs treated with extracellular ATP and LPS

    Enhance the therapeutic efficacy of human umbilical cord-derived mesenchymal stem cells in prevention of acute graft-versus-host disease through CRISPLD2 modulation

    Stem cell research & therapy1 May 2025

Immune response

downin human cells1

1 study

  1. CRISPLD2 inhibits immune response in human cells.

    “In vitro studies demonstrated a marked increase in IL-10 secretion, which enhanced T-cell suppression in CRISPLD2-modified HUC-MSCs.”

    Cellscoculture with CRISPLD2-modified HUC-MSCs in vitro

    Enhance the therapeutic efficacy of human umbilical cord-derived mesenchymal stem cells in prevention of acute graft-versus-host disease through CRISPLD2 modulation

    Stem cell research & therapy1 May 2025

More on Immune response

Latest

Related