Whole-body insulin sensitivity

1. Early time-restricted feeding improves whole-body insulin sensitivity in humans (compared with energy-matched caloric restriction control, free-living) (between-group difference 1.89 (95% CI 0.18, 3.60); P = 0.03).

   “When compared with CON:CR, eTRF improved whole-body insulin sensitivity”

   Human trialcompared with energy-matched caloric restriction control, free-living2 wkmalesn = 16

   Two weeks of early time-restricted feeding (eTRF) improves skeletal muscle insulin and anabolic sensitivity in healthy men

   The American journal of clinical nutrition·Jul 31, 2020

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1. Metformin impairs whole-body insulin sensitivity in humans during aerobic exercise training, metformin vs placebo.

   “However, metformin attenuated the increase in whole-body insulin sensitivity and VO2 max after AET.”

   Human trialduring aerobic exercise training, metformin vs placebo12 weeks

   Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults

   Aging cell·Dec 11, 2018

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1. Acarbose showed no clear effect on whole-body insulin sensitivity in humans.

   “Clamp-derived insulin sensitivity index and body weight were unchanged by the intervention.”

   Human trial100 mg three times daily12 weeksn = 66

   Effects of acarbose treatment on markers of insulin sensitivity and systemic inflammation

   Diabetes technology & therapeutics·Apr 13, 2011

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1. Whole-body insulin sensitivity is associated with oxidative phosphorylation in humans (change from baseline after aerobic exercise training).

   “The change in whole-body insulin sensitivity was correlated to the change in mitochondrial respiration.”

   Human trialchange from baseline after aerobic exercise trainingskeletal muscle12 weeks

   Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults

   Aging cell·Dec 11, 2018

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1. Femoral bone marrow insulin sensitivity is associated with whole-body insulin sensitivity in humans (R = 0.487).

   “FBM insulin sensitivity correlated with whole body insulin sensitivity (R = 0.487, p = 0.001)”

   Humansfemoral bone marrowfemales

   Femoral Bone Marrow Insulin Sensitivity Is Increased by Resistance Training in Elderly Female Offspring of Overweight and Obese Mothers

   PloS one·Sep 26, 2016

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