Cortical area

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White matter hyperintensities

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  1. White matter hyperintensities increase cortical area in humans.

    Humanscortex9 yearsmalesn = 104

    White matter changes accelerate cortical thinning more in men · Human brain mapping · 29 Sep 2026

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Human Brain MappingHumans

White matter changes accelerate cortical thinning more in men

Across nine years in 104 older adults, white matter aberrations grew 7.2% annually, driving accelerated cortical thinning that was more pronounced in…Across nine years in 104 older adults, white matter aberrations grew 7.2% annually, driving accelerated cortical thinning that was more pronounced in men than women.

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