What does the research say about type I interferon?

Type I interferon

There are 17 papers on type I interferon in aging research: none in people yet, 5 in animals, 7 in cells, 5 reviews. The newest story, Oct 30, 2026: “Gene variant linked to greater brain inflammation in aging mice”.

Biomarker

17 papers study it151 more mention it2 findings

7 new papers in 30 daysSee all 168 papers on type I interferon

Animals5
Cells7

Interventions

Taurine

upin reviews1

1 study

Taurine increases type I interferon in one preclinical SLE study.
“Tau aggravated SLE progression characterized by increased generation of type I interferons”
Reviewin one preclinical SLE study
Taurine supplementation and systemic lupus erythematosus in preclinical studies: a systematic review of clinical outcomes and underlying mechanisms
Amino acidsMar 24, 2026

Upstream

cGAS–STING signaling

upin reviews1

1 study

cGAS–STING signaling induces type I interferon.
“Its activation can promote the expression of type I interferons and inflammatory factors”
Review
cGAS-STING signaling in pollution-induced toxicity: mechanism and relieving medication
Apoptosis : an international journal on programmed cell deathMar 3, 2026

Funding

2 grants since 2023

Wellcome Trust£1.9MDanmarks Frie Forskningsfond

Latest

50 papers in 12 months

Free Radical Biology & MedicineAug 29

Gene variant linked to greater brain inflammation in aging mice

Experiments in mice aged 4, 12 and 20 months linked a human gene variant to greater buildup of sugar-modified molecules and inflammatory signaling.Experiments in mice aged 4, 12 and 20 months linked a human gene variant to greater buildup of sugar-modified molecules and inflammatory signaling.

Mouse studyInflammation

Paper

ImmunityJul 14

Flavin adenine dinucleotide is an endogenous suppressor for cytosolic DNA and RNA sensors to modulate innate immunity

Experiments in miceMechanisms

Paper

Amino AcidsMar 24

Taurine supplementation and systemic lupus erythematosus in preclinical studies: a systematic review of clinical outcomes and underlying mechanisms

Systematic review of animal and cell studiesTaurine

Paper

ApoptosisMar 3

cGAS-STING signaling in pollution-induced toxicity: mechanism and relieving medication

ReviewType I interferon signaling

Paper

Leukemia ResearchFeb 7

Clonal hematopoiesis and age-associated degenerative disorders

ReviewBlood and immune system

Paper

Preprints.orgNov 4

The Activation of NF-κB by the SARS-CoV-2 Spike Protein and Its Role in Epigenetic Age Acceleration, Inflammaging, and, Finally, Senescence

Preprint: reviewCellular senescence

Paper

Hearing ResearchNov 2

A time-resolved single-nucleus atlas of cochlear aging reveals biphasic inflammaging and Tbx2-dependent inner hair cell maintenance

Computational studyInflammation

Paper

QJMNov 2

The Hidden Genome Awakens: LINE-1 Retrotransposons as Emerging Regulators of Cardiac Aging and Inflammation

ReviewTransposable element activity

Paper

Journal of Human ImmunityOct 27

Rates of some self-targeting antibodies level off in centenarians

Antibodies that block virus-fighting proteins occurred in 5.4% of 938 centenarians, compared with more than 6% of people over 80 in the general population.Antibodies that block virus-fighting proteins occurred in 5.4% of 938 centenarians, compared with more than 6% of people over 80 in the general population.

Cross-sectional · 938 peoplePopulations