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56 in 12 months

Molecular Pain7 h

Activity-limiting pain linked to muscle gene activity in older adults

A cross-sectional study of 742 adults aged 70 or older linked activity-limiting pain to muscle gene activity patterns that differed between men and women.A cross-sectional study of 742 adults aged 70 or older linked activity-limiting pain to muscle gene activity patterns that differed between men and women.

Cross-sectional · 742 peopleMuscle

Paper

bioRxivOct 14

In Vivo Transcriptomics-Based Framework for Systematic Indication Expansion

Preprint: experiments in rodentsTranscriptomics

Paper

bioRxivOct 13

Lifelong mating reshaped liver aging in short-lived killifish

In killifish experiments, lifelong mating reduced inflammation in old females’ main liver cells, while models based on gene activity predicted “younger” ages for several…In killifish experiments, lifelong mating reduced inflammation in old females’ main liver cells, while models based on gene activity predicted “younger” ages for several liver cell types.

Preprint: fish studyInterventions

Paper

Molecular NeurobiologyOct 11

Integrative Transcriptomic and Interactome Analyses Prioritize Candidate Genes for Alzheimer's Disease

Computational studyMechanisms

Paper

Alzheimer's Research & TherapyOct 4

Aspirin initiation before 65 links to lower Alzheimer's risk

Across electronic health records and insurance claims databases, starting aspirin before age 65 was consistently associated with lower incident Alzheimer’s disease risk.Across electronic health records and insurance claims databases, starting aspirin before age 65 was consistently associated with lower incident Alzheimer’s disease risk.

Cohort study in peopleAspirin

Paper

medRxivOct 2

Elevation in Plasma p-tau217 Concentrations Among Blood Donors: An Exploratory Cross-Sectional Study

Preprint: cross-sectional study of 257 peoplep-Tau217

Paper

bioRxivOct 1

Model infers spatial neighborhoods in dissociated single cells

The computational tool predicted cellular proximity across brain regions and identified age-associated neighborhood remodeling in an 8-month Alzheimer dataset.The computational tool predicted cellular proximity across brain regions and identified age-associated neighborhood remodeling in an 8-month Alzheimer dataset.

Preprint: computational studyAI & data

Paper

Research SquareSep 30