Cells
Loss of body-clock protein linked to more artery plaques in mice
Experiments linked deletion of a body-clock protein in brown fat cells to greater plaque formation in aging and young mice genetically prone to artery disease.Experiments linked deletion of a body-clock protein in brown fat cells to greater plaque formation in aging and young mice genetically prone to artery disease.
Mouse studyMechanisms
Who was studiedAged male ApoE-deficient mice, one year, against littermate control mice
What changedArtery plaque area was higher in aged BMAL1-deficient male mice: 23.37 ± 1.86% versus 15.45 ± 1.34% in controls
The catchDeletion also targets classical brown fat, complicating attribution of plaque changes to fat surrounding arteries