What does the research say about tissue stiffness?

Tissue stiffness

There are 5 papers on tissue stiffness in aging research: 1 observational study in people, 2 in cells, 1 review. The newest story, Nov 2, 2026: “Model suggests how cell behavior shapes lung scarring in aged mice”.

Biomarker

5 papers study it60 more mention it3 findings

4 new papers in 30 daysSee all 65 papers on tissue stiffness

Humans1
Cells2
In silico1

Associations

Cell cycle regulation

upin mice1

1 study

Tissue stiffness is associated with cell cycle regulation in mice.
“Global and compartment-specific analyses associated stiffer regions with lower matrix-related programs and higher cell-cycle programs”
Animalsglobal and compartment-specific analyses of spatially matched stiffness and transcriptome dataovaryn = 2,771
Paired-surface spatial mechanomics links tissue stiffness maps to spatial transcriptomics
bioRxivAug 31, 2026Preprint

Funding

1 grant since 2026

Japan Society for the Promotion of Science¥18.3M

Establishment of a Flexibility Improvement Model Based on Soft Tissue Stiffness Assessment in the Elderly
Japan Society for the Promotion of ScienceUniversity of Tsukuba¥18.3M2026–2030

Latest

24 papers in 12 months

BiogerontologyAug 28

Hardened ground: ECM stiffness as a unifying biomechanical driver of reproductive stem cell aging

ReviewExtracellular matrix

Paper

bioRxivMay 18

Model suggests how cell behavior shapes lung scarring in aged mice

In aged-mouse simulations, cell contact expanded senescent cell numbers, while the timing of their removal by immune cells shaped lung scarring.In aged-mouse simulations, cell contact expanded senescent cell numbers, while the timing of their removal by immune cells shaped lung scarring.

Preprint: computational studyLung