Skeletal muscle glucose uptake

1. Early time-restricted feeding increases skeletal muscle glucose uptake in humans (compared with energy-matched caloric restriction control, after carbohydrate/protein drink) (between-group difference 4266 (95% CI 261, 8270) μmol·min-1·kg-1·180 min; P = 0.04).

   “skeletal muscle uptake of glucose [between-group difference (95% CI): 4266 (261, 8270) μmol·min-1·kg-1·180 min; P = 0.04”

   Human trialcompared with energy-matched caloric restriction control, after carbohydrate/protein drinkskeletal muscle2 wkmalesn = 16

   Two weeks of early time-restricted feeding (eTRF) improves skeletal muscle insulin and anabolic sensitivity in healthy men

   The American journal of clinical nutrition·Jul 31, 2020

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1. O304 increases skeletal muscle glucose uptake in diet-induced obesity.

   “O304, which - in diet-induced obese mice - increased glucose uptake in skeletal muscle”

   Animalsin diet-induced obesityskeletal muscle

   PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients

   JCI insight·Jun 21, 2018

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1. Skeletal muscle glucose uptake is associated with insulin resistance in humans (threshold of less than 33 μmol/kg tissue/min) (less than 33 μmol/kg tissue/min).

   “Skeletal muscle GU less than 33 μmol/kg tissue/min and subcutaneous adipose tissue GU less than 11.5 μmol/kg tissue/min characterized insulin-resistant individuals.”

   Humansthreshold of less than 33 μmol/kg tissue/minskeletal muscle

   Insulin-stimulated glucose uptake in skeletal muscle, adipose tissue and liver: a positron emission tomography study

   European journal of endocrinology·Mar 13, 2018

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