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O304

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab
  • Model organisms1

Outcomes

3

Vasoconstriction

downin rats1

1 study

  1. O304 decreases vasoconstriction in rats.

    “O304 at 2-10 μmol/L dose-dependently relaxed phenylephrine (PE) and U46619-induced pre-constriction”

    Animalsphenylephrine (PE) and U46619-induced pre-constrictionmesenteric artery2-10 μmol/L

    O304 is a mitochondrial uncoupler which extends C. elegans lifespan and induces vasorelaxation of rat mesenteric arteries

    Chemico-biological interactions21 Oct 2025

Mitochondrial membrane potential

downin cells1

1 study

  1. O304 decreases mitochondrial membrane potential in cells.

    “O304 at 2-20 μmol/L dose-dependently reduced the mitochondrial membrane potential”

    Cellsin A10 cells and HepG2 cells2-20 μmol/L

    O304 is a mitochondrial uncoupler which extends C. elegans lifespan and induces vasorelaxation of rat mesenteric arteries

    Chemico-biological interactions21 Oct 2025

More on Mitochondrial membrane potential

Lifespan

upin worms1

1 study

  1. O304 extends lifespan in worms.

    “O304 (100 μmol/L) treatment extended C. elegans lifespan through AMPK-mTOR axis, and autophagy-induced lipid catabolism.”

    Model organisms100 μmol/L

    O304 is a mitochondrial uncoupler which extends C. elegans lifespan and induces vasorelaxation of rat mesenteric arteries

    Chemico-biological interactions21 Oct 2025

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