Skeletal muscle

Biomarker

3 papers study it2,005 more mention it1 finding

Humans3

Associations

Mortality

upin humans1HR 1.49

1 study

Skeletal muscle predicts mortality in humans (HR 1.49).
“and 1.49 for all-cause mortality (low SM) compared to middle categories”
Humansmultivariable-adjustedn = 66,608
Aging-related changes in body composition across the lifespan - insights from over 66.000 individuals of a Western European population
medRxiv : the preprint server for health sciencesMay 23, 2025Preprint

Funding

166 grants since 2017

National Institute on AgingUS$33.4mNational Institute of Arthritis and Musculoskeletal and Skin DiseasesUS$35mNational Institute of Diabetes and Digestive and Kidney DiseasesUS$14.7m

Latest

1,679 papers in 12 months

PLOS ONEOct 23

Comparison of facial muscle activity between younger and older Japanese adults: A cross-sectional study

Study in peopleMechanisms

Paper

Circulation JournalOct 23

Trajectory of Multidimensional Frailty Across Recurrent Heart Failure Hospitalizations ― A Single-Center Longitudinal Cohort Study ―

Cohort study of 337 peopleHeart failure

Paper

Circulation JournalOct 23

Altered Plasma Urea Cycle Metabolites Are Independently Associated With Frailty in Patients With Heart Failure

Cross-sectional study of 413 peopleHeart failure

Paper

Journal of Cachexia, Sarcopenia and MuscleOct 22

Denosumab linked to greater grip strength gains in women

At 12 months, grip strength rose 1.45 kg with denosumab versus 0.66 kg with zoledronic acid in postmenopausal women with osteoporosis.At 12 months, grip strength rose 1.45 kg with denosumab versus 0.66 kg with zoledronic acid in postmenopausal women with osteoporosis.

Cohort · 186 peopleDenosumab

Paper

Frontiers in Cardiovascular MedicineOct 22

Artificial intelligence-enabled deep clinical phenotyping in heart failure with preserved ejection fraction: from patient subtypes to precision care

ReviewHeart failure with preserved ejection fraction

Paper

bioRxivOct 22

Muscle aging patterns differ by sex across six species

Across all six species, researchers identified four female-biased and 18 male-biased aging markers, plus three markers shared by both sexes.Across all six species, researchers identified four female-biased and 18 male-biased aging markers, plus three markers shared by both sexes.

Preprint: cross-sectional studyBiomarkers

Paper

Scientific ReportsOct 22

Aerobic exercise induced skeletal muscle MOTS-c secretion: A novel therapy for MASLD via hepatic ACE2 regulation

Experiments in miceAerobic exercise

Paper

Research SquareOct 22

Frailty links to distinct muscle and protein changes by sex

In 208 older adults, frailty was linked to muscle and bone loss in females, while males showed lower leg strength and altered muscle protein breakdown.In 208 older adults, frailty was linked to muscle and bone loss in females, while males showed lower leg strength and altered muscle protein breakdown.

Preprint: cross-sectional · 208 peopleMuscle

Paper

BMC GeriatricsOct 22

Elastic band resistance training improves physical function, gait, cardiac indices, and corticomuscular coherence in older women at risk of sarcopenia: a randomized controlled trial

Randomized trial in 40 peopleResistance training

Paper

Chinese Journal of GeriatricsOct 22

Diagnostic value of CT-related skeletal muscle parameters at the third lumbar vertebra level for sarcopenia in elderly patients with gastrointestinal tumors

Cross-sectional study of 216 peopleSarcopenia

Paper

Skeletal muscle

Associations

Funding

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