Tirzepatide improves cardiometabolic risk factors in humans.
“tirzepatide treatment was associated with improved cardiometabolic risk factors, that were generally greater in magnitude with higher degrees of body weight reduction among people with obesity and prediabetes.”
Human trialin people with obesity and prediabetespooled 5/10/15 mg dosesWeek 176n = 458
Intermittent fasting improves cardiometabolic risk factors in humans.
“IF regimens improve body composition, ectopic fat, and classic cardiometabolic risk factors, as compared to unrestricted eating, especially in metabolically unhealthy participants.”
Reviewespecially in metabolically unhealthy participants
Cardiometabolic risk factors raise the risk of cardiovascular disease in humans (HR 1.17, 95% CI 1.15-1.19).
“Each additional cardiometabolic risk factor was associated with higher risks of the baseline-to-CVD, baseline-to-death, and CVD-to-death transitions (hazard ratio [HR] 1.17, 95% confidence interval [CI] 1.15-1.19”
Humansamong individuals with MASLDmedian follow-up of 15.9 yearsn = 72,922
National Institute on AgingUS$885.3kNational Institute of Diabetes and Digestive and Kidney DiseasesUS$2.9mNational Heart, Lung, and Blood InstituteUS$602.6k
An observational study of 915 people linked scan-measured fat and muscle characteristics to death risk after catheter-based aortic valve replacement.An observational study of 915 people linked scan-measured fat and muscle characteristics to death risk after catheter-based aortic valve replacement.
Persistent or rising midlife activity was associated with 80% and 79% lower odds of pre-frailty or frailty, respectively, than persistent inactivity after 22 years.Persistent or rising midlife activity was associated with 80% and 79% lower odds of pre-frailty or frailty, respectively, than persistent inactivity after 22 years.
Compared with women retaining their ovaries, the surgery group had no clear difference in blood pressure rises at 24 months (adjusted odds ratio 1.03).Compared with women retaining their ovaries, the surgery group had no clear difference in blood pressure rises at 24 months (adjusted odds ratio 1.03).