Intramuscular adipose tissue content

1. Skeletal muscle oxidative capacity has no effect on intramuscular adipose tissue content in humans.

   “Skeletal muscle oxidative capacity was not related to IntraMAT content.”

   Humansskeletal musclen = 13

   Association of skeletal muscle oxidative capacity with muscle function, sarcopenia-related exercise performance, and intramuscular adipose tissue in older adults

   GeroScience·Dec 28, 2023

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1. Intramuscular adipose tissue content is associated with PaO2/FiO2 ratio in humans (β: -2.360, p = 0.003).

   “High IMATL1 (β: -2.360, p = 0.003) was associated with a greater decrease in the PaO2/FiO2 ratio during hospitalization.”

   Humanssepsis patients with pneumonian = 303

   Chest CT-derived body composition parameters for outcome prediction in sepsis patients with pneumonia

   Annals of medicine·Nov 10, 2025

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1. Metabolic syndrome is associated with intramuscular adipose tissue content in humans.

   “Female MS patients demonstrated significantly more IMAT compared to controls”

   Humansin femalesfemales

   Sex-specific adipose-muscle patterns from CT reveal metabolic syndrome risk in the elderly with machine learning

   Diabetes research and clinical practice·Nov 7, 2025

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1. Intramuscular adipose tissue content predicts major adverse cardiovascular events in humans (HR 1.41).

   “1.41 for incident MACE (high IMAT)”

   Humansmultivariable-adjustedn = 66,608

   Aging-related changes in body composition across the lifespan - insights from over 66.000 individuals of a Western European population

   medRxiv : the preprint server for health sciences·May 23, 2025Preprint

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1. MSTN is associated with intramuscular adipose tissue content in humans.

   “Myostatin decrease was observed in participants who completed a higher median number of exercise sessions and was associated with decreased intramuscular adipose tissue”

   Human trial6 weeks

   Feasibility of telehealth exercise and nicotinamide riboside supplementation in survivors of childhood cancer at risk for diabetes: A pilot randomized controlled trial

   Pediatric blood & cancer·Oct 10, 2024

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1. age is associated with intramuscular adipose tissue content in humans (r = 0.559, p < 0.01).

   “Strong and moderate associations were found between age and MD (r = −0.763, p < 0.01), and age and IMAT (r = 0.559, p < 0.01).”

   Humansn = 30

   HR-pQCT for the Evaluation of Muscle Quality and Intramuscular Fat Infiltration in Ageing Skeletal Muscle

   Journal of personalized medicine·Jun 20, 2022