SIRT6 protein abundance

1. SIRT6 increases SIRT6 protein abundance in human cells.

   “the centenarian variants endogenously elevated SIRT6 protein levels through weakened interaction with vimentin”

   Cellscentenarian SIRT6 missense variants introduced by genomic knock-inhuman embryonic stem cell-derived somatic lineages

   Rare centenarian SIRT6 variants elevate SIRT6 protein levels and resist cellular senescence

   bioRxiv (Cold Spring Harbor Laboratory)·30 Sep 2025Preprint

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