Senescent macrophages

1. Senescent macrophages are associated with Sirius Red collagen content in humans.

   “the senescent macrophage cell population was significantly correlated to the Sirius Red percent area.”

   Human trialat 7 days of recovery after 14 days of unilateral limb immobilizationskeletal muscle7 daysn = 18

   Robust immune cell infiltration and macrophage senescence occur within a week of recovery after limb immobilization in older adult skeletal muscle

   The Journal of physiology·27 Mar 2026

More on Sirius Red collagen content

1. Senescent macrophages are associated with lipid/necrotic core expansion in pigs.

   “These results suggest that development of senescence correlated with LNC size.”

   Animalsin coronary atherosclerotic plaquescoronary artery

   Macrophage senescence is associated with expansion of atherosclerotic plaque’s lipid/necrotic core: implications in plaque destabilization

   AHA Scientific Sessions 2025 abstract·3 Nov 2025