3 papers2 findings
Zonation marker expression
mixedin mice1
Senescence signatures are associated with zonation marker expression in mice.
“Multiple analytic approaches identified distinct age-, zone- and sex-specific senescence signatures, which were significantly associated with zonation markers changes.”
Animalswild-type miceliver
Senescence linked to loss of liver zone identity in mice
bioRxiv : the preprint server for biology10 Aug 2026Preprint
ANXA1
upin humans1
ANXA1 is associated with senescence signatures in humans.
“We identified an expanding ANXA1+ CD8+ naïve subset with senescence signatures and impaired function.”
HumansANXA1+ CD8+ naïve T cell subsetbone marrown = 15
Transplanting ANXA1⁻ CD8⁺ Naïve T cells Delay Aging Through Senolysis
bioRxiv (Cold Spring Harbor Laboratory)23 Feb 2026Preprint
An animal study mapped gene activity in mouse livers of multiple ages, linking senescence patterns to changes in gene patterns defining specialised liver zones.An animal study mapped gene activity in mouse livers of multiple ages, linking senescence patterns to changes in gene patterns defining specialised liver zones.