Papers on ROS generation

323 papers7 new in 30 days

Thursday, November 5

Naunyn-Schmiedeberg's Archives of PharmacologyNov 5

Restoration of mitophagy by crebanine suppresses sevoflurane-induced microglial activation and cognitive deficits by blocking mitochondrial DNA-triggered cGAS–STING pathway

Figure from Naunyn-Schmiedeberg's Archives of Pharmacology

Experiments in ratsInterventions

Paper

Tuesday, October 27

BiomedicinesOct 27

Nicotinamide Mononucleotide Is Associated with Attenuation of OGD/R-Induced Pro-Inflammatory Programs in Microglia: Transcriptomic Evidence Converging on the NLRP3 Inflammasome and Lipid-Droplet-Related Molecular Signatures

Primary microglia identification and mitochondrial ultrastructural changes after OGD/R and NMN treatment.

Experiments in mouse cellsNicotinamide mononucleotide

Paper

PharmaceuticalsOct 27

Co-Supplementation of Policosanol and Atorvastatin Attenuates High-Cholesterol and High-Galactose Diet-Induced Ocular and Brain Damage and Improves Cognitive Health in Zebrafish

Zebrafish swimming ability (open field tank analysis) (n = 10) across the groups after 22 weeks of feeding the specialized diet.

Experiments in 42 zebrafishAtorvastatin

Paper

Current BiologyOct 27

A defense molecule helps flies shed aging gut cells

Experiments in fruit flies identified pileup, a molecule involved in microbial defense, as a regulator of aging gut-cell removal.Experiments in fruit flies identified pileup, a molecule involved in microbial defense, as a regulator of aging gut-cell removal.

Fly studyGut and microbiome

Paper

Monday, October 26

ESC Congress 2026 AbstractOct 26

Inflammation of the calcified aortic valve in cardiac patients is associated with activation of the local aldosterone system, promoting oxidative stress–driven pathological responses

Study in peopleOxidative stress and ROS signaling

Paper

ESC Congress 2026 AbstractOct 26

Pleiotropic effects of canagliflozin and dapagliflozin in cadio-oncology: a novel strategy to balance antitumor efficacy and cardiotoxicity in HER2-positive breast cancer therapy

Experiments in human cellsCanagliflozin

Paper

Saturday, October 24

Journal of Agricultural and Food ChemistryOct 24

Cyclovirobuxine Prevents Osteoclastogenesis and Estrogen Deficiency-Induced Bone Loss by Inhibiting ROS Generation via the PI3K/AKT/FOXO1 Pathway

Experiments in mouse cellsBone loss

Paper

Friday, October 9

Antioxidants & Redox SignalingOct 9

Immune Checkpoint Inhibitor-Induced Cardiovascular Disease: The Role of Accelerated Senescence in Vascular Dysfunction

ReviewCellular senescence

Paper

Wednesday, October 7

Frontiers in Aging NeuroscienceOct 7

A computational-first proof-of-concept for dual-function metal chelation and aggregate neutralization in an Aβ42 Drosophila model

Docking-predicted Aβ42 binding energies of PpIX, chlorin e6, and maltol across the three docking search regions.

Experiments in fliesInterventions

Paper

Wednesday, September 30

Current Atherosclerosis ReportsSep 30

An Update of Oxidative Stress in Atherosclerosis with Emphasis on the LOX-1-NLRP3 Inflammasome Axis

Figure from Current Atherosclerosis Reports

ReviewNLRP3 inflammasome

Paper

Saturday, September 26

BiologySep 26

SIRT1 in Senescence: Mitochondria and Immune Crosstalk

The SIRT1-FOXO antioxidant defense pathway.

ReviewSirtuin signaling

Paper

Thursday, September 17

Preprints.orgSep 17

Convergent Evolution of MT-ND1 Ubiquinone Gatekeeper Signature in Exceptionally Long-Lived Vertebrates

Preprint: computational studyMechanisms

Paper

Wednesday, September 16

Tobacco Induced DiseasesSep 16

Activation of aryl hydrocarbon receptor by cigarette smoke induces oxidative stress, autophagy impairment and cellular senescence

Quantitative summary of cigarette smoke (CS)-induced chronic obstructive pulmonary disease (COPD)-like pulmonary remodeling and epithelial cellular senescence in rat lungs: A) Bar graphs quantify…

Experiments in ratsAutophagy

Paper

Wednesday, September 9

Biomedicine & PharmacotherapySep 9

Redox remodeling of perivascular adipose tissue in vascular aging

Figure from Biomedicine & Pharmacotherapy

ReviewMechanisms

Paper

International Journal of Innovative Technologies in Social ScienceSep 9

THE IMPACT OF PHYSICAL ACTIVITY ON SKIN AGING: THE ROLE OF OXIDATIVE STRESS AND ADAPTIVE MECHANISMS - NARRATIVE REVIEW

ReviewSkin

Paper

Sunday, September 6

Frontiers in Molecular BiosciencesSep 6

Glucan exopolysaccharide from Enterococcus hirae OL616073 alleviates oxidative stress and extends lifespan in different model systems

Figure from Frontiers in Molecular Biosciences

Experiments in wormsInterventions

Paper

Thursday, August 27

AntioxidantsAug 27

A Pyrazole-Based Small Molecule, KB3409, Restores Mitochondrial Function via VCP Activation and RCN2-Dependent Ca²⁺ Regulation

High throughput screening for compounds that lower ROS levels in senescent fibroblasts.

Experiments in human cellsInterventions

Paper

Wednesday, August 26

CellsAug 26

NCOA4-Mediated Ferritinophagy Contributes to Iron Overload-Driven Ferroptosis of Senescent Myoblasts in Mice

Iron overload and ferroptosis occurred in D-gal-induced senescent myoblasts.

Experiments in cellsFerroptosis

Paper

Friday, August 21

bioRxivAug 21

A Standardized In Vitro Platform for Senolytic Drug Discovery in Human Musculoskeletal Cells

Preprint: experiments in human cellsBiomarkers

Paper

Thursday, August 13

Frontiers in AgingAug 13

Mitochondrial respiratory supercomplexes associated with longevity in mammals

Mitochondrial respiratory supercomplexes extend lifespan.

ReviewOxidative phosphorylation

Paper

Wednesday, July 29

Journal of Cachexia, Sarcopenia and MuscleJul 29

Imeglimin reduced muscle wasting in obese and aging mice

Fast-contracting fibers in a hind-leg muscle were 66% larger in cross-section in obese mice given imeglimin than in obese controls after six weeks.Fast-contracting fibers in a hind-leg muscle were 66% larger in cross-section in obese mice given imeglimin than in obese controls after six weeks.

Mouse studyMuscle

Paper

Wednesday, July 15

Free Radical Biology & MedicineJul 15

Resveratrol lengthened young worms’ lives but shortened older ones’

In worm experiments, four days of resveratrol improved healthy lifespan in early adulthood but worsened it in middle age.In worm experiments, four days of resveratrol improved healthy lifespan in early adulthood but worsened it in middle age.

Worm studyResveratrol