Proteasomal activity

1 paper1 finding

Cells1

Upstream

1

FERMT3

upin human cells1

1 study

FERMT3 increases Proteasomal activity in human cells.
“cells expressing miP-FERMT3 exhibited increased global protein ubiquitination, enhanced centrosomal neddylation and elevated proteasomal activity.”
CellsmiP-FERMT3 overexpressionendothelial cell
A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces p53-mediated cell cycle arrest and senescence
bioRxiv (Cold Spring Harbor Laboratory)3 Dec 2025Preprint

Latest

12 in 12 months

Antioxidants26 Sep

Proteasome activity maintains red blood cell integrity during storage and restoration

Inhibiting the proteasome accelerates ATP depletion, protein aggregation, and clearance markers in stored and aged red blood cells.Inhibiting the proteasome accelerates ATP depletion, protein aggregation, and clearance markers in stored and aged red blood cells.

Experiments in human cellsUbiquitin–proteasome system

Nature Communications17 Sep

Quantitative proteomics reveals coordinated changes in the proteome during replicative senescence

Experiments in cellsCellular senescence

Cellular and Molecular Life Sciences18 Aug

Comparative analysis of neuronal proteolytic pathways reveals neuron-specific and sub-compartmental-specific capacities with aging

Experiments in miceMechanisms

Food Research International23 Mar

Fucoxanthin, a bioactive compound derived from edible seaweed, supports proteostasis and protects against stress and senescence

Experiments in wormsInterventions

Journal of Translational Medicine6 Mar

Age-related adiponectin resistance in human skeletal muscle dysfunction: in vivo and in vitro evidence

Cohort study of 393 peopleAutophagy

Biomolecules & Therapeutics27 Feb

Skin Organoids in Proteostasis Research: Early Insights into Aging

ReviewProteostasis

bioRxiv23 Jan

Proteasome activator Blm10 maintains cellular proteostatic balance and gamete quality in budding yeast

Preprint: experiments in yeastUbiquitin–proteasome system

Ageing Research Reviews21 Jan

Proteolysis-targeting chimera (PROTAC): A promising senolytic strategy

ReviewSenolytics

AAIC 2025 Abstract26 Dec

Breaking Barriers in Alzheimer’s: Next‐Gen Small Molecules Targeting USP14 for Neuroprotection and Protein Homeostasis

Experiments in wormsAlzheimer's disease

AAIC 2025 Abstract23 Dec

Proteasome Activation as a Therapeutic Strategy to Rescue Cognitive Decline in Aging and Alzheimer’s Disease

Experiments in miceAlzheimer's disease