FERMT3

1. FERMT3 induces cellular senescence in human cells.

   “These findings identify miP-FERMT3 as a novel regulator of protein catabolism and p53-dependent cell cycle arrest and cellular senescence in endothelial cells.”

   CellsmiP-FERMT3 overexpressionendothelial cell

   A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces p53-mediated cell cycle arrest and senescence

   bioRxiv (Cold Spring Harbor Laboratory)·3 Dec 2025Preprint

More on Cellular senescence

1. FERMT3 induces cell-cycle arrest in human cells.

   “These findings identify miP-FERMT3 as a novel regulator of protein catabolism and p53-dependent cell cycle arrest and cellular senescence in endothelial cells.”

   CellsmiP-FERMT3 overexpressionendothelial cell

   A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces p53-mediated cell cycle arrest and senescence

   bioRxiv (Cold Spring Harbor Laboratory)·3 Dec 2025Preprint

1. FERMT3 increases Proteasomal activity in human cells.

   “cells expressing miP-FERMT3 exhibited increased global protein ubiquitination, enhanced centrosomal neddylation and elevated proteasomal activity.”

   CellsmiP-FERMT3 overexpressionendothelial cell

   A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces p53-mediated cell cycle arrest and senescence

   bioRxiv (Cold Spring Harbor Laboratory)·3 Dec 2025Preprint

More on Proteasomal activity

1. FERMT3 is associated with age in silico.

   “Analyses of independent murine and human transcriptomic and proteomic aging datasets further revealed that FERMT3 expression and protein abundance increase with age.”

   In silicotranscriptomic and proteomic aging datasetsendothelial cell

   A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces p53-mediated cell cycle arrest and senescence

   bioRxiv (Cold Spring Harbor Laboratory)·3 Dec 2025Preprint

2. FERMT3 is associated with age in silico.

   “Analyses of independent murine and human transcriptomic and proteomic aging datasets further revealed that FERMT3 expression and protein abundance increase with age.”

   In silicotranscriptomic and proteomic aging datasetsendothelial cell

   A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces p53-mediated cell cycle arrest and senescence

   bioRxiv (Cold Spring Harbor Laboratory)·3 Dec 2025Preprint