Organ age
Biomarker2 papers2 findings
- Human trial1
- Humans1
Interventions
1Exercise
upin humans1downin humans1Very low certainty
1 study
Exercise
upin humans1downin humans1Very low certainty
Exercise increases organ age in humans.
Human trialadipose, brain, heart, immune, and liverendurance exercise training20 weeksn = 657
Endurance Exercise Modifies Organ-Specific Proteomic Aging Scores: Insights from the Heritage Family Study · AHA Scientific Sessions 2025 abstract · 3 Nov 2025
Exercise decreases organ age in humans.
Human trialkidney, muscle, and pancreasendurance exercise training20 weeksn = 657
Endurance Exercise Modifies Organ-Specific Proteomic Aging Scores: Insights from the Heritage Family Study · AHA Scientific Sessions 2025 abstract · 3 Nov 2025
Latest
22Deleting the mechanosensitive channel Piezo1 prevents gut motility decline in aging mice
Age-related gut stiffening activates smooth muscle Piezo1, triggering calcium signaling that suppresses contractile genes and slows intestinal…Age-related gut stiffening activates smooth muscle Piezo1, triggering calcium signaling that suppresses contractile genes and slows intestinal transit.
Inherited and somatic components in the pathogenetics of common diseases
Proteomic organ clocks predict mortality but trail established physiological and epigenetic biomarkers
In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.
Blood methylation framework maps dependencies between aging hallmarks and organ aging
A new computational tool links cellular maintenance modules to tissue-specific age patterns across two human cohorts totaling over two thousand…A new computational tool links cellular maintenance modules to tissue-specific age patterns across two human cohorts totaling over two thousand participants.
Organ age acceleration and mortality risk reflect distinct biological processes
Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from…Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from mortality.
Blood and facial photos track organ aging and senescence scores in humans
Researchers used transcriptomic models, DNA methylation, and images across multiple human cohorts to infer tissue-specific biological age and hallmark…Researchers used transcriptomic models, DNA methylation, and images across multiple human cohorts to infer tissue-specific biological age and hallmark burdens.
Aging alters neutrophil states across multiple organs in mice
Single-cell profiling of young and aged mice revealed organ-specific neutrophil remodeling, showing subsets enriched for inflammatory and IL-6…Single-cell profiling of young and aged mice revealed organ-specific neutrophil remodeling, showing subsets enriched for inflammatory and IL-6 pathways that induced senescence-linked responses in vitro.