Oral glucose tolerance

1. Acarbose showed no clear effect on oral glucose tolerance in humans (75 g oral glucose tolerance test before and after study).

   “A 75 g oral glucose tolerance test was performed before and after the study, the difference not being significant in either the acarbose group or the placebo group.”

   Human trial75 g oral glucose tolerance test before and after study100 mg tds24 weeks

   Long-term effect of acarbose on glycaemic control in non-insulin-dependent diabetes mellitus: a placebo-controlled double-blind study

   Diabetic medicine : a journal of the British Diabetic Association·Mar 1, 1993

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1. SIRT1 showed no clear effect on oral glucose tolerance in mice (combined with GCN5 knockout in tamoxifen-induced dTG mice compared with WT littermates).

   “There was no difference in oral glucose tolerance, skeletal muscle contractile function, mitochondrial abundance, or maximal respiratory capacity between dTG and WT mice.”

   Animalscombined with GCN5 knockout in tamoxifen-induced dTG mice compared with WT littermates

   Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice

   American journal of physiology. Endocrinology and metabolism·Dec 3, 2019

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