Semaglutide was linked to 40% lower relative risk of major cardiovascular events over 365 days than nonuse in adults with obesity and heart failure with reduced ejection…Semaglutide was linked to 40% lower relative risk of major cardiovascular events over 365 days than nonuse in adults with obesity and heart failure with reduced ejection fraction.
Fall risk was higher among users than matched non-users, with a risk ratio of 1.142 during follow-up lasting up to five years.Fall risk was higher among users than matched non-users, with a risk ratio of 1.142 during follow-up lasting up to five years.
An observational analysis followed 4,177 Black adults for a median 12 years; the association held in people with and without anemia.An observational analysis followed 4,177 Black adults for a median 12 years; the association held in people with and without anemia.
More fat around the heart and within muscle was linked to cardiovascular events, with hazard ratios (relative-risk measures) of 1.31 and 1.38, respectively, versus lower…More fat around the heart and within muscle was linked to cardiovascular events, with hazard ratios (relative-risk measures) of 1.31 and 1.38, respectively, versus lower levels.
Modeled adherence to all recommendations was linked to adult diabetes risk 2.6 percentage points lower and obesity risk 5.9 percentage points lower than observed.Modeled adherence to all recommendations was linked to adult diabetes risk 2.6 percentage points lower and obesity risk 5.9 percentage points lower than observed.
Frail patients had a higher risk of major heart and blood vessel events at one year than non-frail patients; the hazard ratio, a relative-risk measure, was 1.38.Frail patients had a higher risk of major heart and blood vessel events at one year than non-frail patients; the hazard ratio, a relative-risk measure, was 1.38.
In 12,299 Korean screening participants, the authors reported that adjusted probabilities matched observed artery-calcium frequencies to approximately within one…In 12,299 Korean screening participants, the authors reported that adjusted probabilities matched observed artery-calcium frequencies to approximately within one percentage point.
Who was studied12,299 Korean screening participants
What changedAdjusted artery-calcium predictions matched observed frequencies to approximately within one percentage point in the independent Korean cohort
The catchThe analysis measured prediction accuracy, not whether model use improved health outcomes
Combined use was linked to a lower rate of major limb complications over time than use of neither class, with a hazard ratio of 0.50.Combined use was linked to a lower rate of major limb complications over time than use of neither class, with a hazard ratio of 0.50.
With no coronary artery calcium, more severe obesity was linked to a 35–58% higher adjusted relative risk of major cardiovascular events than normal weight.With no coronary artery calcium, more severe obesity was linked to a 35–58% higher adjusted relative risk of major cardiovascular events than normal weight.
In postmenopausal women with excess weight, gut-hormone drugs were linked to 31% and 42% lower relative risks versus nonuse alongside systemic estrogen-only and…In postmenopausal women with excess weight, gut-hormone drugs were linked to 31% and 42% lower relative risks versus nonuse alongside systemic estrogen-only and estrogen-plus-progesterone therapy, respectively.
Who was studiedPostmenopausal women with excess weight receiving systemic hormones, up to 3 years
What changedCombined death, stroke or vein-clot risk was 31% lower with estrogen-only and 42% lower with estrogen-plus-progesterone among drug starters versus nonusers
The catchDiabetes prevalence differed despite matching, potentially confounding the combined death, stroke, and clot outcome
Calorie restriction producing 20% weight loss reduced time spent in an irregular heart rhythm to 22.7 seconds, versus 227 seconds in obese mice without weight loss.Calorie restriction producing 20% weight loss reduced time spent in an irregular heart rhythm to 22.7 seconds, versus 227 seconds in obese mice without weight loss.
Each 0.11-unit rise in an activity-rest rhythm measure was linked to a 25% lower relative risk of atrial fibrillation, an irregular heartbeat.Each 0.11-unit rise in an activity-rest rhythm measure was linked to a 25% lower relative risk of atrial fibrillation, an irregular heartbeat.
High-intensity statin use was linked to lower dementia risk than no statin use, with a relative risk measure called a hazard ratio of 0.54.High-intensity statin use was linked to lower dementia risk than no statin use, with a relative risk measure called a hazard ratio of 0.54.
A modeled 30-minute daily shift from sedentary time to moderate-to-vigorous activity was linked to a relative diagnosis rate of 0.87 versus unchanged behavior.A modeled 30-minute daily shift from sedentary time to moderate-to-vigorous activity was linked to a relative diagnosis rate of 0.87 versus unchanged behavior.
The drugs were associated with lower mortality than metformin alone, with a hazard ratio of 0.55, but no significant reduction in limb complications.The drugs were associated with lower mortality than metformin alone, with a hazard ratio of 0.55, but no significant reduction in limb complications.
Sleep scores of one and two had adjusted hazard ratios of 0.907 and 1.117 versus zero, relative death-rate measures whose uncertainty ranges included no difference.Sleep scores of one and two had adjusted hazard ratios of 0.907 and 1.117 versus zero, relative death-rate measures whose uncertainty ranges included no difference.
Who was studied33,661 adults without diabetes and with elevated BMI
What changedCardiovascular death risk was higher with sleep problems and advanced heart-kidney-metabolic risk together than their separate effects would predict
The catchSleep impairment scores relied partly on self-reported sleep trouble, making them vulnerable to reporting errors
In advanced kidney disease, 10-point higher health behavior scores were linked to lower cardiovascular mortality, with a hazard ratio of 0.829.In advanced kidney disease, 10-point higher health behavior scores were linked to lower cardiovascular mortality, with a hazard ratio of 0.829.
The model scored 0.810 on a measure of distinguishing people who developed atrial fibrillation within 10 years from those who did not.The model scored 0.810 on a measure of distinguishing people who developed atrial fibrillation within 10 years from those who did not.
Among adults with low 10-year risk but high 30-year risk or high “bad” cholesterol, 47.71% progressed to higher risk categories within five years.Among adults with low 10-year risk but high 30-year risk or high “bad” cholesterol, 47.71% progressed to higher risk categories within five years.
Seven-year rates of atrial fibrillation, an irregular heartbeat, were 6.4% in people flagged by an artificial intelligence heart-tracing model, versus 2.1% in those not…Seven-year rates of atrial fibrillation, an irregular heartbeat, were 6.4% in people flagged by an artificial intelligence heart-tracing model, versus 2.1% in those not flagged.
