Normative Modeling

There is 1 paper on Normative Modeling in aging research: 1 observational study in people. The newest story, Nov 13, 2026: “Brain scan model performs best in dementia detection tests”.

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7 new papers in 30 daysSee all 95 papers on Normative Modeling

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Dec 2025: 8Jan 2026: 6Feb 2026: 4Mar 2026: 4Apr 2026: 6May 2026: 3Jun 2026: 5Jul 2026: 3Aug 2026: 5Sep 2026: 2Oct 2026: 5Nov 2026: 253 papers in 12 months
Communications Medicine

Brain scan model performs best in dementia detection tests

Trained on scans from 29,883 people and validated in 7,013 others, the model performed best among compared approaches to detecting dementia and mild cognitive impairment.Trained on scans from 29,883 people and validated in 7,013 others, the model performed best among compared approaches to detecting dementia and mild cognitive impairment.

Cross-sectional · 7,013 peopleFrontotemporal dementia
Translational Psychiatry

Aging measure linked to smaller brain regions in young adults

An observational analysis of 254 adults aged 28–30 also linked the DNA-based measure to lower intelligence-test scores in women.An observational analysis of 254 adults aged 28–30 also linked the DNA-based measure to lower intelligence-test scores in women.

Cross-sectional · 254 peopleBiomarkers
Nature Communications

Brain maps capture memory-region differences across disorders

An observational analysis used brain scans from 34,789 healthy people to assess memory-region volumes in 3,521 patients with neurological disorders.An observational analysis used brain scans from 34,789 healthy people to assess memory-region volumes in 3,521 patients with neurological disorders.

Cross-sectional · 3,521 peopleNeurological disease
bioRxiv

Brain network patterns linked to biology across the lifespan

An observational analysis of resting brain scans from 5,349 people aged 6–80 linked age-related network patterns to cellular and molecular maps.An observational analysis of resting brain scans from 5,349 people aged 6–80 linked age-related network patterns to cellular and molecular maps.

Preprint: cross-sectional · 3,834 peopleMechanisms
medRxiv

One brain region was smaller than expected in neurological disease

An observational study of 81,870 UK Biobank participants aged 45–87 linked lower-than-expected volume in this region to later dementia and Parkinson’s disease.An observational study of 81,870 UK Biobank participants aged 45–87 linked lower-than-expected volume in this region to later dementia and Parkinson’s disease.

Preprint: case-control · 43 peopleMechanisms
arXiv

Brain charts linked to progression to dementia in people

An observational analysis found that brain-structure measures added information about progression to mild cognitive impairment and dementia beyond a clinical rating of…An observational analysis found that brain-structure measures added information about progression to mild cognitive impairment and dementia beyond a clinical rating of impairment.

Preprint: cohort studyDementia
Neuroscience Bulletin

Brain scans may help distinguish neurological disorders

An observational study used brain scans from 22,258 healthy participants as references for 4,132 patients, finding distinct patterns across neurological conditions.An observational study used brain scans from 22,258 healthy participants as references for 4,132 patients, finding distinct patterns across neurological conditions.

Cross-sectional study of 22,258 peopleNeurological disease
bioRxiv

Normative brain models reveal dopamine shifts in early amyloid

In cognitively unimpaired older adults, intermediate amyloid burden showed lower dopamine-transporter deviation scores than amyloid-positive status, with an adjusted…In cognitively unimpaired older adults, intermediate amyloid burden showed lower dopamine-transporter deviation scores than amyloid-positive status, with an adjusted difference of −0.582.

Preprint: cohort study of 4,152 peopleBiomarkers

See all 95 papers on Normative Modeling