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Silymarin, quercetin and naringenin

Intervention

1 paper6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: “la Caixa” Foundation and 3 more
  • Animals1

Outcomes

6

NF-κB

downin rats1

1 study

  1. Silymarin, quercetin and naringenin decreases NF-κB in rats.

    “In addition, polyphenolic treatments increased SIRT1 levels and decreased NF-κB levels in hippocampus.”

    AnimalsAged Sprague-Dawley ratshippocampus20 mg/kg/day4 weeksmales

    Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats

    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology14 Aug 2017

More on NF-κB

SIRT1

upin rats1

1 study

  1. Silymarin, quercetin and naringenin increases SIRT1 in rats.

    “In addition, polyphenolic treatments increased SIRT1 levels and decreased NF-κB levels in hippocampus.”

    AnimalsAged Sprague-Dawley ratshippocampus20 mg/kg/day4 weeksmales

    Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats

    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology14 Aug 2017

More on SIRT1

Tryptophan hydroxylase and tyrosine hydroxylase activity

upin rats1

1 study

  1. Silymarin, quercetin and naringenin increases tryptophan hydroxylase and tyrosine hydroxylase activity in rats.

    “Polyphenols reversed the age-induced deficits in monoaminergic neurotransmitters (serotonin, noradrenaline, and dopamine), increasing TPH and TH activity.”

    AnimalsAged Sprague-Dawley ratsbrain20 mg/kg/day4 weeksmales

    Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats

    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology14 Aug 2017

More on Tryptophan hydroxylase and tyrosine hydroxylase activity

Serotonin, noradrenaline and dopamine

upin rats1

1 study

  1. Silymarin, quercetin and naringenin increases serotonin, noradrenaline and dopamine in rats.

    “Polyphenols reversed the age-induced deficits in monoaminergic neurotransmitters (serotonin, noradrenaline, and dopamine), increasing TPH and TH activity.”

    AnimalsAge-induced monoaminergic neurotransmitter deficitsbrain20 mg/kg/day4 weeksmales

    Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats

    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology14 Aug 2017

More on Serotonin, noradrenaline and dopamine

Motor coordination

upin rats1

1 study

  1. Silymarin, quercetin and naringenin improves motor coordination in rats.

    “Results indicated that chronic polyphenolic treatments showed restorative effects on cognition and motor coordination consistently with the biochemical and molecular results.”

    AnimalsLong-term administration of silymarin, quercetin or naringenin in aged Sprague-Dawley rats20 mg/kg/day4 weeksmales

    Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats

    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology14 Aug 2017

Cognitive function

upin rats1

1 study

  1. Silymarin, quercetin and naringenin improves cognitive function in rats.

    “Results indicated that chronic polyphenolic treatments showed restorative effects on cognition and motor coordination consistently with the biochemical and molecular results.”

    AnimalsLong-term administration of silymarin, quercetin or naringenin in aged Sprague-Dawley rats20 mg/kg/day4 weeksmales

    Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats

    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology14 Aug 2017

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