Neutrophils
Biomarker4 papers2 findings
- Humans2
- Animals1
Interventions
1Maraviroc
downin mice1Very low certainty
1 study
Maraviroc
downin mice1Very low certainty
Maraviroc decreases neutrophils in mice.
Animals
Cytotoxic CD4⁺ T cells induce age-associated myelopoiesis through CCL5-CCR5 signaling · Nature aging · 26 Aug 2026
Effects
1Cognitive decline
mediatesin humans1
1 study
Cognitive decline
mediatesin humans1
Neutrophils mediate cognitive decline in humans (7.39%).
Humanssmoke-cognitive decline association
Roles of smoke exposure and inflammatory biomarkers in cognitive function among older adults: Findings from two prospective cohort studies · Journal of Alzheimer's disease : JAD · 8 Sep 2026
Funding
National Heart, Lung, and Blood InstituteUS$1.4mNational Institute on AgingUS$1.6mNational Institute of Neurological Disorders and StrokeUS$574.7k5 grants since 2023
National Institute of Neurological Disorders and StrokeIcahn School of Medicine at Mount SinaiUS$574.7k2026–2027
Elucidating mechanisms informing age-related changes in neutrophil function and migration
National Institute on AgingUniversity of Wisconsin-madisonUS$41.1k2026–2030
Neutrophils play a pivotal role in vascular aging
National Heart, Lung, and Blood InstituteBoston University Medical CampusUS$203.9k2023–2027
National Institute on AgingNew York University School of MedicineUS$1.5m2025–2030
Regulation of inflammation in myeloid progenitors and neutrophils by RUNX1
National Heart, Lung, and Blood InstituteUniversity of PennsylvaniaUS$635.4k2026–2030
Latest
82A Non-Endoscopic Dynamic Nomogram for Atrophic Gastritis Risk Stratification Based on Serum Indicators and Clinical Factors
Association of anxiety, depressive symptoms, and inflammatory indices with cardiometabolic multimorbidity
High neutrophil-to-lymphocyte ratio predicts cognitive decline
During five years of follow-up, 42.55% of older adults with high ratios progressed to mild cognitive impairment or dementia compared with 30.82% with…During five years of follow-up, 42.55% of older adults with high ratios progressed to mild cognitive impairment or dementia compared with 30.82% with normal ratios.
Blood cell composition explains substantial variation in DNA methylation age
Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.
Biomimetic nanozymes reduce neuroinflammation and cognitive decline in aged mice
Neutrophil-coated nanoparticles crossed the blood-brain barrier, altered microglial metabolism, and improved cognitive performance after surgery in…Neutrophil-coated nanoparticles crossed the blood-brain barrier, altered microglial metabolism, and improved cognitive performance after surgery in older mice.
Aging alters neutrophil states across multiple organs in mice
Single-cell profiling of young and aged mice revealed organ-specific neutrophil remodeling, showing subsets enriched for inflammatory and IL-6…Single-cell profiling of young and aged mice revealed organ-specific neutrophil remodeling, showing subsets enriched for inflammatory and IL-6 pathways that induced senescence-linked responses in vitro.