Angewandte Chemie Novit
Compounds boost a protein’s two gene-control roles in cells
Laboratory screening identified compounds that enhanced a protein’s ability both to suppress gene activity and to activate it.Laboratory screening identified compounds that enhanced a protein’s ability both to suppress gene activity and to activate it.
Human cell studyMechanisms
Who was studiedHuman cells
What changedThe lead compound boosted both TLX gene-control roles, with 8.6-fold activation of its gene-switching-on function
The catchEngineered reporter assays supplied the evidence for boosting both gene-control roles