Mitochondrial heteroplasmy

1. Mitochondrial heteroplasmy impairs glucose metabolism in mice.

   “culminating in impaired glucose metabolism”

   Animalsin OriL of mtDNA

   Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

   Scientific reports·Apr 12, 2018

1. Mitochondrial heteroplasmy shortens lifespan in mice.

   “These conplastic mice demonstrate a shorter lifespan”

   Animalsin OriL of mtDNA

   Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

   Scientific reports·Apr 12, 2018

1. COVID-19 increases mitochondrial heteroplasmy in humans.

   “We found a higher burden of total heteroplasmic variants in COVID-19 patients compared to controls with a selective increment in ND1 and COIII genes.”

   HumansCOVID-19

   Association of Inflammatory Mediators with Mitochondrial DNA Variants in Geriatric COVID-19 Patients

   Aging and disease·Feb 9, 2024

More on COVID-19

1. Age has no effect on mitochondrial heteroplasmy in M. myotis.

   “Cohort data showed no significant increase in heteroplasmy with age”

   AnimalsWild bats; cohort analysisbloodn = 195

   Population level mitogenomics of long-lived bats reveals dynamic heteroplasmy and challenges the Free Radical Theory of Ageing

   Scientific reports·Sep 11, 2018

1. Mitochondrial heteroplasmy is associated with high-risk clonal hematopoiesis and myeloid neoplasia in humans.

   “heteroplasmy associates with high risk clonal haematopoiesis and myeloid neoplasia”

   Review

   Barcode, Passenger, or Driver? Mitochondrial Heteroplasmy in the Somatic Evolution of Human Haematopoiesis

   Research Square·Oct 19, 2026Preprint

More on High-risk clonal hematopoiesis and myeloid neoplasia

1. Mitochondrial heteroplasmy is associated with neutral passenger behavior during hematopoietic clonal expansion in humans.

   “many age associated mitochondrial heteroplasmies in blood behave predominantly as neutral passengers exposed by haematopoietic clonal expansion.”

   Reviewage-associated mitochondrial heteroplasmiesblood

   Barcode, Passenger, or Driver? Mitochondrial Heteroplasmy in the Somatic Evolution of Human Haematopoiesis

   Research Square·Oct 19, 2026Preprint

1. Mitochondrial heteroplasmy is associated with inflammation in humans.

   “Both heteroplasmic variant burden and low-level heteroplasmy were associated with increased levels of IL-6, TNF-α, and IFN-α.”

   HumansCOVID-19 patients

   Association of Inflammatory Mediators with Mitochondrial DNA Variants in Geriatric COVID-19 Patients

   Aging and disease·Feb 9, 2024

More on Inflammation

1. time is associated with mitochondrial heteroplasmy in M. myotis.

   “longitudinal data from recaptured individuals showed heteroplasmy is dynamic, and does not increase uniformly over time.”

   AnimalsLongitudinal analysis of recaptured individualsbloodMultiple years

   Population level mitogenomics of long-lived bats reveals dynamic heteroplasmy and challenges the Free Radical Theory of Ageing

   Scientific reports·Sep 11, 2018