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MT-CO3

Gene

4 papers4 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Bundesministerium für Bildung und Forschung and 1 more
  • Humans1
  • Animals2
  • In silico1

Effects

4

Synaptic long-term potentiation

no changein mice1

1 study

  1. MT-CO3 has no effect on synaptic long-term potentiation in mice.

    “could not detect significant differences in synaptic long-term potentiation”

    Animalsin C57BL/6 J-mtNOD mice

    Mitochondrial complex IV mutation increases reactive oxygen species production and reduces lifespan in aged mice

    Acta physiologica (Oxford, England)20 Nov 2018

Lifespan

downin mice1

1 study

  1. MT-CO3 shortens lifespan in mice.

    “the median lifespan of mtNOD mice was significantly shorter than of control animals”

    Animalsin C57BL/6 J-mtNOD mice

    Mitochondrial complex IV mutation increases reactive oxygen species production and reduces lifespan in aged mice

    Acta physiologica (Oxford, England)20 Nov 2018

SOD2

downin mice1

1 study

  1. MT-CO3 decreases SOD2 in mice.

    “reduced gene expression of superoxide dismutase 2 in the 24-month-old mtNOD mouse”

    Animalsin C57BL/6 J-mtNOD mice

    Mitochondrial complex IV mutation increases reactive oxygen species production and reduces lifespan in aged mice

    Acta physiologica (Oxford, England)20 Nov 2018

More on SOD2

Mitochondrial superoxide

upin mice1

1 study

  1. MT-CO3 increases mitochondrial superoxide in mice.

    “we observed an elevated mitochondrial superoxide production”

    Animalsin C57BL/6 J-mtNOD mice

    Mitochondrial complex IV mutation increases reactive oxygen species production and reduces lifespan in aged mice

    Acta physiologica (Oxford, England)20 Nov 2018

More on Mitochondrial superoxide

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