1 paper1 finding
Inhibiting lipid biosynthesis
downin worms1
Inhibiting lipid biosynthesis decreases mitochondrial fission in worms.
“inhibiting lipid biosynthesis reduces mitochondrial fission and facilitates hypoxic survival.”
Model organismshypoxia
Conserved lipid metabolic reprogramming confers hypoxic and aging resilience
EMBO reports11 Dec 2025
In bone marrow stem cells linked to senile osteoporosis, lamin B1 loss triggered a form of cell death that disrupted mitochondria and impaired bone formation.In bone marrow stem cells linked to senile osteoporosis, lamin B1 loss triggered a form of cell death that disrupted mitochondria and impaired bone formation.
In aged mice, lacking Sestrin1 worsened liver cell senescence and fat buildup, and the protein proved indispensable for the liver benefits of exercise.In aged mice, lacking Sestrin1 worsened liver cell senescence and fat buildup, and the protein proved indispensable for the liver benefits of exercise.
In an osteoporosis animal model, mitochondria from treated stem cells promoted blood vessel formation and restored the structure of spongy bone.In an osteoporosis animal model, mitochondria from treated stem cells promoted blood vessel formation and restored the structure of spongy bone.
The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.