Inhibiting lipid biosynthesis
1 paper4 findings
- 1 lab in 1 country
- Funders: American Heart Association and 4 more
- Model organisms1
Outcomes
4APOE4-induced pathologies
downin worms1
1 study
APOE4-induced pathologies
downin worms1
Inhibiting lipid biosynthesis protects against APOE4-induced pathologies in worms.
“inhibiting lipid biosynthesis protects against APOE4-induced pathologies and aging trajectories in C. elegans.”
Model organismsAPOE4
Conserved lipid metabolic reprogramming confers hypoxic and aging resilience
EMBO reports11 Dec 2025
Hypoxic survival
upin worms1
1 study
Hypoxic survival
upin worms1
Inhibiting lipid biosynthesis improves hypoxic survival in worms.
“inhibiting lipid biosynthesis reduces mitochondrial fission and facilitates hypoxic survival.”
Model organismshypoxia
Conserved lipid metabolic reprogramming confers hypoxic and aging resilience
EMBO reports11 Dec 2025
Mitochondrial fission
downin worms1
1 study
Mitochondrial fission
downin worms1
Inhibiting lipid biosynthesis decreases mitochondrial fission in worms.
“inhibiting lipid biosynthesis reduces mitochondrial fission and facilitates hypoxic survival.”
Model organismshypoxia
Conserved lipid metabolic reprogramming confers hypoxic and aging resilience
EMBO reports11 Dec 2025
Hypoxic resilience
upin U. parryii cells1
1 study
Hypoxic resilience
upin U. parryii cells1
Inhibiting lipid biosynthesis improves hypoxic resilience in U. parryii cells.
“Inhibiting lipid biosynthesis recapitulates hypoxic resilience of squirrel NSCs.”
Cellshypoxic resilience
Conserved lipid metabolic reprogramming confers hypoxic and aging resilience
EMBO reports11 Dec 2025