1 paper2 findings
Age-related pathology
upin mice1
mtDNA mutations induce age-related pathology in mice.
“mutations that arise during the first two months of life are sufficient to drive a wide variety of age-related pathologies”
Animals
Early-life mitochondrial DNA mutations drive age-related pathology in mice
bioRxiv27 Sep 2026Preprint
POLG
upin mice1
POLG increases mtDNA mutations in mice.
“expresses a proofreading-deficient version of mtDNA polymerase-gamma (PolgA), resulting in accelerated accumulation of mtDNA mutations”
Reviewproofreading-deficient PolgA expression
GSA 2025 abstract31 Dec 2025
National Institute on AgingUS$1.1mNational Eye InstituteUS$98.5kNational Institute of Diabetes and Digestive and Kidney DiseasesUS$194.4k
National Institute on AgingUniversity of WashingtonUS$121.4k2022–2027
Tissue-Specific Modulation of mtDNA Mutations: Exploring Aging and Lifestyle Interventions
National Institute on AgingUniversity of Rhode IslandUS$567.2k2026–2031
Characterizing the role of mitochondrial DNA mutations on retinal degeneration.
National Eye InstituteCleveland Clinic Lerner Com-cwruUS$49.5k2024–2027
Triggering the Selective Removal of Deleterious mtDNA Mutations from Mammalian Cells
National Institute on AgingUniversity of Southern CaliforniaUS$49k2024–2025
National Institute of Diabetes and Digestive and Kidney DiseasesUniversity of WashingtonUS$194.4k2021–2024
Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.