MechanismsAnimals
A Novel Inducible mtDNA Mutator Mouse Model to Study Mitochondrial Dysfunction with Temporal and Spatial Control
GSA 2025 Abstract
Abstract
Mitochondrial dysfunction is a hallmark of aging and numerous age-related diseases. A wealth of studies supports the accumulation of mitochondrial DNA (mtDNA) mutations as a driving factor of mitochondrial dysfunction in aging and disease.
