Metabolic signatures
Biomarker3 papers3 findings
- Humans3
Effects
3Pulmonary hypertension
mediatesin humans1
1 study
Pulmonary hypertension
mediatesin humans1
Metabolic signatures mediate pulmonary hypertension in humans (11.74% (95% CI 7.91%-18.95%)).
Humans13.58 years
Long-term ambient air pollution exposure, metabolomic signatures, and incident pulmonary hypertension: A large prospective cohort study · Ecotoxicology and environmental safety · 9 Sep 2026
Pulmonary embolism
mediatesin humans1
1 study
Pulmonary embolism
mediatesin humans1
Metabolic signatures mediate pulmonary embolism in humans (21.1% (95% CI, 12.8-28.4)).
Humansin womenfemales
Association of Limb Fat Distribution and Plasma Metabolites With the Risk of Venous Thromboembolism · Journal of thrombosis and haemostasis : JTH · 7 Sep 2026
Venous thromboembolism
mediatesin humans1
1 study
Venous thromboembolism
mediatesin humans1
Metabolic signatures mediate venous thromboembolism in humans (15.2% (95% CI, 6.8-21.9)).
Humansin womenfemales
Association of Limb Fat Distribution and Plasma Metabolites With the Risk of Venous Thromboembolism · Journal of thrombosis and haemostasis : JTH · 7 Sep 2026
Latest
18Biological aging and frailty linked to thinner central retinas
Blood metabolic profiles statistically accounted for 81.14% of the link with one biological age measure, compared with 19.92% for another and 32.27%…Blood metabolic profiles statistically accounted for 81.14% of the link with one biological age measure, compared with 19.92% for another and 32.27% for frailty.
More functional deficits linked to depression and anxiety
Scores of four or more versus zero were linked to higher risks of depression and anxiety, with hazard ratios of 3.96 and 3.03, respectively.Scores of four or more versus zero were linked to higher risks of depression and anxiety, with hazard ratios of 3.96 and 3.03, respectively.
Metabolic signature links frailty to coronary artery disease
A 36-metabolite signature mediated an estimated 18.5% of the association between frailty and incident coronary artery disease over a median 14.8-year…A 36-metabolite signature mediated an estimated 18.5% of the association between frailty and incident coronary artery disease over a median 14.8-year follow-up.
Killifish exhibit distinct structural changes and fibrosis during cardiac aging
Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical…Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical cardiomyocyte hypertrophy.
Six blood metabolites distinguish metabolic health in obesity
A combined clinical-metabolomic model discriminated healthy from unhealthy obesity with an AUC of 0.78, compared with 0.69 for clinical variables…A combined clinical-metabolomic model discriminated healthy from unhealthy obesity with an AUC of 0.78, compared with 0.69 for clinical variables alone.
Spiny mouse fibroblasts favor glycolysis and resist stress
Ear pinna fibroblasts from fetal, young, and old spiny mice maintained low-respiring, spherical mitochondria and stayed resistant to oxidative stress…Ear pinna fibroblasts from fetal, young, and old spiny mice maintained low-respiring, spherical mitochondria and stayed resistant to oxidative stress throughout the lifespan.