Fatty acids

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HeartHumans

H-FABP links to heart risks mostly when omega-3s are low

Highest versus lowest H-FABP tertiles had an MI hazard ratio of 2.23 in people with low omega-3s, but 1.11 in those with high levels.Highest versus lowest H-FABP tertiles had an MI hazard ratio of 2.23 in people with low omega-3s, but 1.11 in those with high levels.

bioRxivModel organismsPreprint

Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies

Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged…Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.

Cell ReportsAnimals

Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice

Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and…Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.

FASEB JournalAnimals

4-Octyl itaconate restores parotid gland function in aging mice

The itaconate derivative reduces fibrosis and lipid buildup while curbing oxidative stress through AMPK signaling pathways.The itaconate derivative reduces fibrosis and lipid buildup while curbing oxidative stress through AMPK signaling pathways.