Papers on liver fibrosis

457 papers29 new in 30 days

Monday, November 2

Nutrition, Metabolism, and Cardiovascular DiseasesNov 2

Fibrosis-4 index and all-cause mortality in MASLD/NAFLD and cardiometabolic populations: a systematic review with structured synthesis without meta-analysis (SWiM)

Meta-analysis of observational studiesFibrosis-4 Index

Saturday, October 31

Diabetology InternationalOct 31

Baseline monocyte GIP receptor mRNA expression is associated with reductions in body weight and FIB-4 index after switching to tirzepatide in patients with type 2 diabetes

Cohort study of 90 peopleTirzepatide

Friday, October 30

Frontiers in NutritionOct 30

Sarcopenic Obesity Was Associated with MASLD in Elderly Chinese: A Multi-centre Community Study

Accepted, not yet published: cross-sectional study of 1,690 peopleSarcopenic obesity

Frontiers in EndocrinologyOct 30

Factors associated with significant liver fibrosis in patients with type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease: a single-center retrospective study

Cross-sectional study of 1,355 peopleMetabolic dysfunction-associated steatotic liver disease

Frontiers in EndocrinologyOct 30

MASLD VCTE-C Cohort: A Prospective Multicenter Study Linking Liver Fibrosis to Cardiovascular Outcomes in Patients with Metabolic Dysfunction–Associated Steatotic Liver Disease

Accepted, not yet published: study protocolAI & data

Frontiers in EndocrinologyOct 30

Metabolic Dysfunction-Associated Steatohepatitis and Type 2 Diabetes: Insulin Resistance, Liver–Pancreas Crosstalk, and Integrated Therapeutic Strategies

Accepted, not yet published: reviewMetabolic dysfunction-associated steatohepatitis

Journal of Alzheimer's Disease ReportsOct 30

Blood protein links to dementia vary with liver scarring score

In 48,754 dementia-free UK Biobank participants, nine blood proteins had links to later dementia that differed with a liver scarring index.In 48,754 dementia-free UK Biobank participants, nine blood proteins had links to later dementia that differed with a liver scarring index.

Cohort · 48,754 peopleAll-cause dementia

Thursday, October 29

LiversOct 29

What Is the Role of GLP-1 Receptor Agonists in the Treatment of MASLD: A Narrative Review

ReviewGLP-1 receptor agonists

JACC AdvancesOct 29

Fatty liver helped predict heart and liver risks

An observational study of 313,970 UK Biobank participants found that fatty liver measures improved risk prediction beyond staging heart, kidney and metabolic health.An observational study of 313,970 UK Biobank participants found that fatty liver measures improved risk prediction beyond staging heart, kidney and metabolic health.

Cohort · 313,970 peopleBiomarkers

Monday, October 26

ESC Congress 2026 AbstractOct 26

Combined liver and other health risks linked to higher mortality

Adults with high liver risk and advanced heart-kidney-metabolic risk had 621% higher relative mortality risk than those with low liver risk and early-stage risk.Adults with high liver risk and advanced heart-kidney-metabolic risk had 621% higher relative mortality risk than those with low liver risk and early-stage risk.

A large scarred liver contrasts with a smaller smooth liver, beside hearts and kidneys with differing interiors and scattered upright figures.

Cohort · 28,056 peoplePopulations

ESC Congress 2026 AbstractOct 26

Stage specific associations between FIB-4 index and cardiovascular kidney metabolic syndrome: a population-based study

Cross-sectional study of 23,654 peopleAdvanced cardiovascular-kidney-metabolic syndrome

ESC Congress 2026 AbstractOct 26

MAF-5 score and cT1 for cardiovascular risk: evidence from UK Biobank

Cohort study of 27,052 peopleIncident cardiovascular disease

ESC Congress 2026 AbstractOct 26

Dynamic changes in liver fibrosis and the risk of death and bleeding in non-cirrhotic patients with atrial fibrillation treated with NOACs

Cohort study of 733 peopleLiver fibrosis

ESC Congress 2026 AbstractOct 26

Fibrosis-4 (FIB-4) score is associated with early diastolic dysfunction in metabolic dysfunction-associated steatotic liver disease (MASLD)

Cross-sectional study of 4,056 peopleDiastolic dysfunction

ESC Congress 2026 AbstractOct 26

Non-invasive assessment of liver fibrosis with FIB-4 for risk stratification and prognosis in ambulatory heart failure

Cohort study of 1,233 peopleFIB-4

Friday, October 23

AIMS Public HealthOct 23

Joint association of insulin resistance, fatty liver and fibrosis indices with MACE and mortality in individuals with Cardiovascular-Kidney-Metabolic syndrome stages 0-3

Associations of insulin resistance–fatty liver/fibrosis indices with MACE and mortality in individuals with Cardiovascular-Kidney-Metabolic syndrome stages 0–3.

Cohort study of 259,699 peopleCardiovascular-kidney-metabolic syndrome

Frontiers in Cardiovascular MedicineOct 23

Liver scarring score linked to heart failure and rhythm disorders

Higher scores were linked to heart rhythm disorders and heart failure, with hazard ratios (relative rates over time) of 1.32 and 1.29, respectively.Higher scores were linked to heart rhythm disorders and heart failure, with hazard ratios (relative rates over time) of 1.32 and 1.29, respectively.

Study population flow chart.

Cohort · 416,001 peopleHeart disease

Tuesday, October 20

Hepatology CommunicationsOct 20

High liver scarring score linked to poorer thinking skills

An observational analysis followed 2,490 Finnish adults for 11 years, linking high liver scarring scores with poorer overall cognitive performance and word-list learning.An observational analysis followed 2,490 Finnish adults for 11 years, linking high liver scarring scores with poorer overall cognitive performance and word-list learning.

Flowchart of the study population.

Cohort · 2,490 peoplePopulations

Naunyn-Schmiedeberg's Archives of PharmacologyOct 20

Anti-inflammatory versus metabolic therapy in MASLD: a randomized clinical trial of aspirin and dapagliflozin using fibroscan outcomes

Randomized trial in 80 peopleAspirin

CureusOct 20

Frequency and Clinical Correlates of Sarcopenia in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease

Cross-sectional study of 276 peopleMetabolic dysfunction-associated steatotic liver disease

Journal of Obesity & Metabolic SyndromeOct 20

Cumulative Exposure to High Systemic Inflammation and Incident Metabolic Dysfunction-Associated Steatotic Liver Disease: A Longitudinal Cohort Study

Cohort study of 9,725 peopleMetabolic dysfunction-associated steatotic liver disease

Saturday, October 17

Archives of Gerontology and GeriatricsOct 17

A pathway may link liver protein clumps and senescence in mice

Experiments in two mouse models of liver disease found protein clumps alongside signs of senescence, a state in which cells stop dividing.Experiments in two mouse models of liver disease found protein clumps alongside signs of senescence, a state in which cells stop dividing.

Mouse studyCellular senescence

Friday, October 16

Giornale Italiano Di Medicina Del Lavoro Ed ErgonomiaOct 16

P032 | NIGHT WORK AND METABOLIC ALTERATIONS IN HEALTHCARE PERSONNEL: AN OBSERVATIONAL STUDY

Cross-sectional study of 383 peoplePopulations

Thursday, October 15

Journal of Alzheimer's Disease ReportsOct 15

Prediction of dementia-related mortality in metabolic dysfunction-associated steatotic liver disease using survival machine-learning models

Clinical features ranked by model importance.

Cohort study of 1,774 peopleMetabolic dysfunction-associated steatotic liver disease

Archives of Medical ScienceOct 15

Daily sedentary behavior exceeding 5 hours is independently associated with MAFLD: a cross-sectional study from NHANES 2017-2020

Flowchart showing the selection of study participants CAP – controlled attenuation parameter.

Cross-sectional study of 7,705 peoplePopulations

Monday, October 12

Scientific ReportsOct 12

Drug linked to reduced liver scarring in mice

In mouse experiments, drug use was also associated with partial recovery of signaling in cells lining the liver’s smallest blood vessels.In mouse experiments, drug use was also associated with partial recovery of signaling in cells lining the liver’s smallest blood vessels.

Experiments in miceInterventions

Sunday, October 11

Liver ResearchOct 11

Context-dependent duality of senescent cells in liver fibrosis

ReviewCellular senescence

Friday, October 9

Journal of Veterinary Medical ScienceOct 9

Aging brain lesions of a 60-year-old Bornean orangutan (Pongo pygmaeus)

Orangutan, gross findings, brain, formalin fixed.

Experiments in animalsMechanisms

Thursday, October 8

Sensors and Actuators B ChemicalOct 8

Hepatic-targeting dual-channel fluorescent probe activated by β-Gal and ONOO- for tracking liver senescence and senolysis process

Experiments in animalsBiomarkers

Friday, October 2

CureusOct 2

Fibrosis-Driven Cardiovascular Risk in Metabolic Dysfunction-Associated Steatotic Liver Disease: Emerging Links With Atherosclerotic Cardiovascular Disease

PRISMA flow diagram of the study selection process.

ReviewMechanisms