Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia · Oct 1, 2026
P032 | NIGHT WORK AND METABOLIC ALTERATIONS IN HEALTHCARE PERSONNEL: AN OBSERVATIONAL STUDY
INTRODUCTION: Night work has been associated with metabolic alterations and an increased risk of metabolic liver diseases. However, among healthcare personnel, the relationship between exposure to night shifts and the risk of liver fibrosis remains poorly defined. FIB-4 is a useful noninvasive index for identifying individuals at greater risk of liver fibrosis. OBJECTIVES: To assess the association between night work and the risk of liver fibrosis, estimated using the FIB-4 index, in a population of healthcare workers undergoing periodic health surveillance. METHODS: A cross-sectional observational study was conducted on 383 healthcare workers at Tor Vergata University Hospital. The population was divided into night-shift and non-night-shift workers. Clinical and laboratory data from health surveillance were analyzed, including: age, sex, BMI, blood pressure, blood glucose, HDL, AST, ALT, platelets and FIB-4. Univariate analyses, stratification by age group and multivariable logistic regression were performed. RESULTS: Non-night-shift workers had higher mean FIB-4 values than night-shift workers (0.943 vs 0.824; p=0.00146). The prevalence of elevated FIB-4 was 15.6% among non-night-shift workers and 8.1% among night-shift workers (p=0.0264). However, non-night-shift workers were older on average (median 48 vs 40 years; p