Papers on liver fibrosis

462 papers29 new in 30 days

Thursday, October 1

Korean Journal of MedicineOct 1

Management of Obesity in Liver Cirrhosis: A Delicate Balance of Risks and Benefits

ReviewCirrhosis

Tuesday, September 29

Journal of HepatologySep 29

EASL-EASD-EASO Guidance for the Use of Resmetirom and Semaglutide as MASH-Targeted Therapy

Figure from Journal of Hepatology

ReviewIndustry & policy

Monday, September 28

Advanced ScienceSep 28

Alternate-day fasting curbs liver fibrosis in mice

In mouse models, alternate-day fasting stimulated hepatocyte nitric oxide production to suppress stellate cell activation, an effect abolished by hepatocyte eNOS…In mouse models, alternate-day fasting stimulated hepatocyte nitric oxide production to suppress stellate cell activation, an effect abolished by hepatocyte eNOS deletion.

scRNA‐seq reveals eNOS expression in hepatocytes in human and mouse liver tissue.

Experiments in miceLiver fibrosis

Thursday, September 24

medRxivSep 24

The Alpha-1 Antitrypsin Z-allele associates with sarcopenia in the UK Biobank

Prevalence of FFMI-defined sarcopenia across AAT genotypes.

Preprint: cohort study of 487,207 peopleSarcopenia

Monday, September 21

Acta Pharmaceutica Sinica BSep 21

Targeting senescent cells with dipeptidyl peptidase 4-CAR-NK cells alleviates liver fibrosis and reverses metabolic dysfunction

Figure from Acta Pharmaceutica Sinica B

Experiments in miceLiver fibrosis

Saturday, September 19

Nutrition, Metabolism, and Cardiovascular DiseasesSep 19

Association of lipoprotein(a) and MASLD in predicting carotid atherosclerosis in asymptomatic individuals: a large scale cross-sectional and longitudinal study

Figure from Nutrition, Metabolism, and Cardiovascular Diseases

Cohort study of 61,139 peopleCarotid atherosclerosis

Thursday, September 17

American Heart Journal PlusSep 17

Cardiovascular disease risk in patients with and without metabolic dysfunction-associated steatotic liver disease: A clinical and subclinical evaluation

Figure from American Heart Journal Plus

ReviewMetabolic dysfunction-associated steatotic liver disease

Wednesday, September 16

Frontiers in EndocrinologySep 16

Association of MASLD with chronic kidney disease according to metabolic profiles and fibrosis severity: a KNHANES analysis

Flowchart of the study population selection.

Cross-sectional study of 17,229 peopleMetabolic dysfunction-associated steatotic liver disease

Thursday, September 10

Clinical Gastroenterology and HepatologySep 10

Assessing Strategies to Mitigate the Effect of Age When Using FIB-4 Index to Screen for MASLD-Related Liver Fibrosis

Figure from Clinical Gastroenterology and Hepatology

Cohort study of 938 peopleFIB-4

Wednesday, September 9

Advances in Laboratory MedicineSep 9

Routine biochemical indices for hepatometabolic stratification across the dysglycaemia spectrum: insulin resistance, fibrosis scores, and machine-learning integration

Correlation matrix of age, metabolic biomarkers, and derived clinical indices.

Cohort study of 1,949 peopleLiver fibrosis

Monday, September 7

Respiratory InvestigationSep 7

Association of liver fibrosis with incident chronic obstructive pulmonary disease

Figure from Respiratory Investigation

Cohort study of 444,376 peopleChronic obstructive pulmonary disease

Clinical and Experimental HypertensionSep 7

Associations of antihypertensive medication class with liver fibrosis and mortality in US adults with MASLD

Cohort study of 458 peopleLiver fibrosis

Thursday, September 3

Journal of Frailty, Sarcopenia and FallsSep 3

Sarcopenia in Indian Males Having Clinically Significant Liver Fibrosis in Type 2 Diabetes: A Tertiary-Centre Cross-Sectional Study to Estimate the Prevalence and Associated Factors

The flow of the current study, LSM – Liver Stiffness Measurement.

Cross-sectional study of 131 peopleSarcopenia

Medical Science MonitorSep 3

Trends in Comorbidities and Fatalities Among First-Time Hepatitis B Hospitalizations in Poland (2012-2023)

Overall distribution of ICD-10 comorbidity categories among patients hospitalized for the first time due to HBV infection, from 2012 to 2023.

Cohort study in peopleHepatitis B

Saturday, August 29

Frontiers in MedicineAug 29

Mapping GLP-1 receptor agonist research across the MASLD-MASH-HCC continuum: a bibliometric and translational analysis

Study selection and bibliometric analysis workflow.

Computational studyGLP-1 receptor agonists

Friday, August 28

Journal of GastroenterologyAug 28

Semaglutide in Japanese participants with metabolic dysfunction-associated steatohepatitis: a subgroup analysis of the ESSENCE trial

Figure from Journal of Gastroenterology

Randomized trial in 116 peopleSemaglutide

Frontiers in GastroenterologyAug 28

The menopause-obesity axis in MASH progression: from estrogen decline to liver fibrosis

Proposed mechanistic pathway linking menopause, obesity, and MASH progression.

ReviewMechanisms

Saturday, August 22

MedicineAug 22

Composite dietary antioxidant index with hepatic indices for predicting mortality in cardiovascular-kidney-metabolic syndrome: Integrated analysis of a nationwide cohort study using machine learning approaches

Flowchart of participant selection across 9 NHANES cycles (2001–2018).

Cohort study in peopleCardiovascular-kidney-metabolic syndrome

Advances in TherapyAug 22

Impact of Menopause and Menopausal Hormone Therapy on Liver-Kidney-Metabolic Health

Figure from Advances in Therapy

ReviewKidney

Thursday, August 20

Acta CardiologicaAug 20

Joint association between FIB-4 index and advanced cardiovascular-kidney-metabolic syndrome with aortic valve calcification: a community cohort in China

Cohort study of 2,884 peopleAortic valve calcification

Korean Journal of Family MedicineAug 20

Association between serum homocysteine levels and mortality stratified by liver fibrosis index: a retrospective cohort study of US adults

Cohort study of 16,541 peoplePopulations

Wednesday, August 19

Advanced ScienceAug 19

Engineering CAR-Macrophages With Advanced Delivery Systems for Tissue Repair

Figure from Advanced Science

ReviewInterventions

Monday, August 17

Experimental NeurologyAug 17

Pathological α-synuclein propagation via the gut-liver axis induces liver injury in gut-origin Parkinson's disease mouse models

Figure from Experimental Neurology

Experiments in miceGut and microbiome

Friday, August 14

Frontiers in EndocrinologyAug 14

Association of the fibrosis-4 index with prevalent diabetes among adults: a cross-sectional analysis of NHANES 2003-2018 and a Chinese hospital-based health examination population

Flowchart of participant selection in NHANES 2003-2018.

Cross-sectional study of 35,213 peopleFibrosis-4 Index

Thursday, August 13

Proteomics Clinical ApplicationsAug 13

Identification of Pre-Diagnostic Protein Biomarkers for Liver Cirrhosis Based on Prospective Analysis of a Large-Scale Plasma Proteomics in the UK Biobank

Cohort study of 40,000 peoplePlasma proteins

Friday, August 7

Clinical Journal of the American Society of NephrologyAug 7

Metabolic Dysfunction-Associated Steatotic Liver Disease, Cardiovascular, and Kidney Disease: Triple Challenges

ReviewCardiovascular-kidney-metabolic syndrome

Tuesday, August 4

Journal of the American Geriatrics SocietyAug 4

Evaluation of Hospital Readmission and Mortality Risk in Older Frail Patients Using the FIB-4 Index: A Cohort Study

Cohort study of 248 peopleFIB-4

Advances in Biology & Earth SciencesAug 4

Moderate Exercise Mitigates Age-Dependent NAFLD Through Modulation of ER Stress Pathways

Experiments in 24 ratsMetabolic dysfunction-associated steatotic liver disease

Monday, August 3

Cell TransplantationAug 3

Generation of bioengineered liver grafts densely recellularized using human liver organoids

Experiments in pigsInterventions

Thursday, July 30

Journal of GastroenterologyJul 30

Tofogliflozin alters amino acid metabolism in gut microbiota linked to hepatic transcriptomic signatures in MASLD

Randomized trial in peopleMetabolic dysfunction-associated steatotic liver disease