National Institute on AgingUS$2.6mNational Institute of Neurological Disorders and StrokeUS$3.5mNational Institute of Diabetes and Digestive and Kidney DiseasesUS$873.2k
Non-Contrast-Enhanced MRI for Brain Perfusion Mapping of Lewy Body Dementia
National Institute of Neurological Disorders and StrokeUniversity of WashingtonUS$440.1k2024–2029
Digital Accessible Remote Olfactory Mediated Health Assessments for Lewy Body Disease
National Institute on AgingAromhaUS$494k2025–2027
Improving End-of-Life Care for Hospitalized Patients with Lewy Body Disorders
National Institute on AgingUniversity of PennsylvaniaUS$194.9k2024–2029
Role of altered gut immune response in Lewy Body Disease
National Institute of Diabetes and Digestive and Kidney DiseasesStanford UniversityUS$215k2024–2029
National Institute of Neurological Disorders and StrokeColumbia University Health SciencesUS$3m2025–2029
National Institute on AgingInstitute for Molecular MedicineUS$1.8m2024–2029
The Proactive and Reactive Neuromechanics of Instability in Aging and Dementia with Lewy Bodies
National Institute on AgingUniv of North Carolina Chapel HillUS$38.7k2024–2026
In a memory clinic cohort, probable REM sleep behaviour disorder was linked to incident Lewy body dementia with a hazard ratio of 4.82.In a memory clinic cohort, probable REM sleep behaviour disorder was linked to incident Lewy body dementia with a hazard ratio of 4.82.
Combined occipito-parietal cortex pathology and striatal dopamine loss predicted conversion to dementia with Lewy bodies with a sub-distribution hazard ratio of 38.68.Combined occipito-parietal cortex pathology and striatal dopamine loss predicted conversion to dementia with Lewy bodies with a sub-distribution hazard ratio of 38.68.
A Mendelian randomization analysis found total cholesterol mediated 93.91% of statins' effect on overall dementia and 84.37% on dementia in Alzheimer's disease.A Mendelian randomization analysis found total cholesterol mediated 93.91% of statins' effect on overall dementia and 84.37% on dementia in Alzheimer's disease.
A phenome-wide study of 367,757 All of Us participants linked APOE alleles to 27 phenotypes, finding ancestry-specific risks for dementia and fatty liver disease.A phenome-wide study of 367,757 All of Us participants linked APOE alleles to 27 phenotypes, finding ancestry-specific risks for dementia and fatty liver disease.
In an autopsy study of 265 decedents, vessel mineralization appeared in 58.3% of globus pallidus samples, 28.6% of posterior hippocampus samples, and 13.8% of putamen…In an autopsy study of 265 decedents, vessel mineralization appeared in 58.3% of globus pallidus samples, 28.6% of posterior hippocampus samples, and 13.8% of putamen samples.
Lewy body disease prevalence rose from 0.7% in individuals younger than 50 to 20.0% in those aged 90 and older across 2,480 autopsied human brains.Lewy body disease prevalence rose from 0.7% in individuals younger than 50 to 20.0% in those aged 90 and older across 2,480 autopsied human brains.