Braak stage
Biomarker1 paper1 finding
- Humans1
Associations
1DNA methylation
upin humans1
1 study
DNA methylation
upin humans1
DNA methylation is associated with Braak stage in humans.
“Intriguingly, nearly all DNAm differences significantly associated with both age (at death) and AD Braak stage showed concordant effect sizes in the same direction.”
Humansassociated with both age and AD Braak stageprefrontal cortex
From aging to Alzheimer's disease: concordant brain DNA methylation changes in late life · AAIC 2025 abstract · 9 Jan 2026
Latest
38Blood eMTBR-tau linked to Alzheimer’s tangles at autopsy
Classification accuracy remained high (AUC=0.91–0.95) up to a decade before death, with higher sensitivity and specificity than plasma p-tau217.Classification accuracy remained high (AUC=0.91–0.95) up to a decade before death, with higher sensitivity and specificity than plasma p-tau217.
Higher education is linked to lower Alzheimer pathology in women
In an autopsy cohort of 2,592 older adults, higher education was linked to lower amyloid and tau pathology in female participants but not in males.In an autopsy cohort of 2,592 older adults, higher education was linked to lower amyloid and tau pathology in female participants but not in males.
Lewy body disease tracks with cognitive decline and psychosis
Lewy body disease prevalence rose from 0.7% in individuals younger than 50 to 20.0% in those aged 90 and older across 2,480 autopsied human brains.Lewy body disease prevalence rose from 0.7% in individuals younger than 50 to 20.0% in those aged 90 and older across 2,480 autopsied human brains.