Hippocampal iron

1. Hippocampal iron increases P-TAU181 in humans (β = 0.217, p = 0.011).

   “and positively associated with plasma p ‐tau181 (β=0.217, p = 0.011, Figure 2B)”

   Humansplasma2.7 ± 0.4 yearsn = 143

   Longitudinal hippocampal iron accumulation predicts episodic memory in presymptomatic Alzheimer's disease with additional influences of tau and APOE geneotype

   AAIC 2025 abstract·7 Jan 2026

More on P-TAU181

1. Hippocampal iron impairs episodic memory in humans (β = -0.223, p = 0.009).

   “Changes in iron levels were significantly negatively correlated with memory performance (β=‐0.223, p = 0.009, Figure 2A)”

   Humanshippocampus2.7 ± 0.4 yearsn = 143

   Longitudinal hippocampal iron accumulation predicts episodic memory in presymptomatic Alzheimer's disease with additional influences of tau and APOE geneotype

   AAIC 2025 abstract·7 Jan 2026