Brain iron
3 papers2 findings
- Humans3
Associations
2Cognitive function
downin humans1
1 study
Cognitive function
downin humans1
Brain iron is associated with cognitive function in humans (p <0.024).
“elevated iron level were independently associated with faster decline in global cognition and three cognitive domains (episodic, semantic, and perceptual speed) (all p <0.024).”
Humansinferior temporal cortexn = 680
AAIC 2025 abstract23 Dec 2025
Cerebral amyloid angiopathy
upin humans1
1 study
Cerebral amyloid angiopathy
upin humans1
Cerebral amyloid angiopathy is associated with brain iron in humans (Est=0.018, SE=0.004, p = <0.001).
“CAA was associated with higher iron levels (Est=0.018, SE=0.004, p = <0.001).”
Humansinferior temporal cortexn = 680
AAIC 2025 abstract23 Dec 2025
Funding
1 grant since 2021National Institute on AgingUS$3.3m
Latest
12 in 12 monthsBrain Research Bulletin
Cross-organ crosstalk in brain-aging-related sarcopenia: Caudate iron accumulation impairs muscle health via blood-brain barrier dysfunction
Mendelian randomisation in peopleMuscle
Free Radical Research
The role of overdose folic acid in promoting neuroinflammation, oxidative stress, and apoptosis in SOD1-G93A mice
Experiments in miceFolic acid
Radiological Physics and Technology
Does quantitative susceptibility mapping elucidate age-related alterations in deep gray matter iron deposition? A systematic review
Systematic review of observational studiesBiomarkers
International Journal of Molecular Sciences
Exercise and Ferroptosis in Neurodegenerative Diseases: Direct Evidence, Mechanistic Links, and Translational Gaps
ReviewExercise
Brain, Behavior, and Immunity
Impact of brain and blood iron on glial density in aging, and relations to cognition: evidence from a 5-year longitudinal multimodal MRI-PET study
Cohort study of 39 peopleMechanisms
Acta Neuropathologica
Cerebral amyloid angiopathy, brain iron concentrations, and cognitive decline in older people
Study in peopleMechanisms
AAIC 2025 Abstract
Longitudinal hippocampal iron accumulation predicts episodic memory in presymptomatic Alzheimer's disease with additional influences of tau and APOE geneotype
Cohort study of 143 peopleMechanisms
AAIC 2025 Abstract
Reduced Face Perception in Aging Linked to Iron Accumulation in Face‐Processing Brain Regions
Cohort study of 18 peopleMechanisms
AAIC 2025 Abstract
Role of brain iron on cerebral amyloid angiopathy and decline in cognition specifically perceptual speed in older people
Cohort study of 680 peopleMechanisms